EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR007440 Chorismate--pyruvate lyase

Protein matches Help

UniProtKB

Matches:

434 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR007440 Chorismate--pyruvate_lyase

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04345	Chor_lyase	434
Signatures in BioMart

GO Term annotation Help

Process

GO:0006744 ubiquinone biosynthetic process

Function

GO:0008813 chorismate lyase activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

Chorismate--pyruvate lyase catalyses the first step in ubiquinone synthesis, the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate in Escherichia coli and other Gram-negative bacteria [1]. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine [2], however this enzyme is found only in bacteria. Its activity does not require metal cofactors [3].

Structural links Help

PDB - click here

SCOP: d.190.1.1

CATH: 3.40.1410.10

Database links Help

Enzyme: EC:4.1.3.40

PANDIT: PF04345

Pfam Clan: CL0122.7

Taxonomic coverage Help

Example proteins Help

P26602 Chorismate--pyruvate lyase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007440	Chorismate--pyruvate lyase
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Nichols BP, Green JM. Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase. J. Bacteriol. 174 5309-16 1992 [PubMed: 1644758] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=1644758&action=stream&blobtype=pdf
2.	Meganathan R. Ubiquinone biosynthesis in microorganisms. FEMS Microbiol. Lett. 203 131-9 2001 [PubMed: 11583838] http://dx.doi.org/10.1111/j.1574-6968.2001.tb10831.x
3.	Siebert M, Severin K, Heide L. Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase. Microbiology (Reading, Engl.) 140 ( Pt 4) 897-904 1994 [PubMed: 8012607]

Additional Reading Open in usermanual
	Smith N, Roitberg AE, Rivera E, Howard A, Holden MJ, Mayhew M, Kaistha S, Gallagher DT. Structural analysis of ligand binding and catalysis in chorismate lyase. Arch. Biochem. Biophys. 445 2006 72-80 [PubMed: 16343413]
	Gallagher DT, Mayhew M, Holden MJ, Howard A, Kim KJ, Vilker VL. The crystal structure of chorismate lyase shows a new fold and a tightly retained product. Proteins 44 2001 304-11 [PubMed: 11455603] http://dx.doi.org/10.1002/prot.1095

InterPro 23.1