EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR007375 Sarcosine oxidase, gamma subunit

Protein matches Help

UniProtKB

Matches:

300 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR007375 SoxG

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04268	SoxG	300
Signatures in BioMart

InterPro Relationships Help

Children

IPR006280 Sarcosine oxidase, gamma subunit, heterotetrameric

InterPro annotation

Entry Details in BioMart

Abstract

Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD⁺. This enzyme catalyzes the oxidative demethylation of sarcosine to yield glycine, H₂O₂, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O₂ [1, 2].

Database links Help

PANDIT: PF04268

Pfam Clan: CL0289.2

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR007375

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

Q46338 Sarcosine oxidase subunit gamma

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006280	Sarcosine oxidase, gamma subunit, heterotetrameric
IPR007375	Sarcosine oxidase, gamma subunit
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Eschenbrenner M, Chlumsky LJ, Khanna P, Strasser F, Jorns MS. Organization of the multiple coenzymes and subunits and role of the covalent flavin link in the complex heterotetrameric sarcosine oxidase. Biochemistry 40 5352-67 2001 [PubMed: 11330998] http://dx.doi.org/10.1021/bi010101p
2.	Chlumsky LJ, Zhang L, Jorns MS. Sequence analysis of sarcosine oxidase and nearby genes reveals homologies with key enzymes of folate one-carbon metabolism. J. Biol. Chem. 270 18252-9 1995 [PubMed: 7543100] http://dx.doi.org/10.1074/jbc.270.31.18252

InterPro 23.1