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InterPro: IPR007356 tRNA (guanine-N1-)-methyltransferase, eukaryotic

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232 proteins

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Accession

IPR007356 tRNA_m1G_MeTrfase_euk

Type

Family

Signatures Help

Database	ID	Name	Proteins
PANTHER	PTHR13563	DUF425	232
Signatures in BioMart

InterPro Relationships Help

Parent

IPR016009 tRNA (guanine-N1-)-methyltransferase

Children

IPR016653 tRNA (guanine-N(1)-)-methyltransferase, metazoa

InterPro annotation

Entry Details in BioMart

Abstract

In transfer RNA many different modified nucleosides are found, especially in the anticodon region. tRNA (guanine-N1-)-methyltransferase EC:2.1.1.31 is one of several nucleases operating together with the tRNA-modifying enzymes before the formation of the mature tRNA. It catalyses the reaction:

S-adenosyl-L-methionine + tRNA -> S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine

methylating guanosine(G) to N1-methylguanine (1-methylguanosine (m1G)) at position 37 of tRNAs that read CUN (leucine), CCN(proline), and CGG (arginine) codons. The presence of m1G improves the cellular growth rate and the polypeptide steptime and also prevents the tRNA from shifting the reading frame [1].

The mechanism of the trmD3-induced frameshift involving mutant tRNA(Pro) and tRNA(Leu) species has been investigated [2]. It has been suggested that the conformation of the anticodon loop may be a major determining element for the formation of m1G37 in vivo [3].

Family member HYNA is the product of a novel gene expressed in human liver cancer tissue.

Database links Help

Enzyme: EC:2.1.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR007356

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

Q09287 Uncharacterized protein C56G2.3

Q12400 tRNA (guanine-N(1)-)-methyltransferase TRM10

Q3UFY8 Mitochondrial ribonuclease P protein 1

Q6PF06 RNA (guanine-9-)-methyltransferase domain-containing protein 3

Q7JUX9 Mitochondrial ribonuclease P protein 1 homolog

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016653	tRNA (guanine-N(1)-)-methyltransferase, metazoa
IPR007356	tRNA (guanine-N1-)-methyltransferase, eukaryotic
IPR016009	tRNA (guanine-N1-)-methyltransferase
	ModBase

Publications Open in usermanual
1.	Hagervall TG, Ericson JU, Esberg KB, Li JN, Bjork GR. Role of tRNA modification in translational fidelity. Biochim. Biophys. Acta 1050 263-6 1990 [PubMed: 2207153] http://dx.doi.org/10.1016/0167-4781(90)90178-5
2.	Hagervall TG, Tuohy TM, Atkins JF, Bjork GR. Deficiency of 1-methylguanosine in tRNA from Salmonella typhimurium induces frameshifting by quadruplet translocation. J. Mol. Biol. 232 756-65 1993 [PubMed: 7689113] http://dx.doi.org/10.1006/jmbi.1993.1429
3.	Qian Q, Bjork GR. Structural requirements for the formation of 1-methylguanosine in vivo in tRNA(Pro)GGG of Salmonella typhimurium. J. Mol. Biol. 266 283-96 1997 [PubMed: 9047363] http://dx.doi.org/10.1006/jmbi.1996.0789

InterPro 23.1