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InterPro: IPR007229 Nicotinate phosphoribosyltransferase-related

Protein matches Help

UniProtKB

Matches:

1666 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR007229 Nic_PRibTrfase-rel

Secondary

IPR006406

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF000484	NAPRT	1592
PANTHER	PTHR11098:SF1	NAPRTase	1520
Signatures in BioMart

InterPro Relationships Help

Parent

IPR015977 Nicotinate phosphoribosyltransferase-like

Children

IPR006405 Nicotinate phosphoribosyltransferase putative
IPR006406 Nicotinate phosphoribosyltransferase

GO Term annotation Help

Process

GO:0019363 pyridine nucleotide biosynthetic process

Function

GO:0004516 nicotinate phosphoribosyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate-limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This family also contains a number of closely related proteins for which a catalytic activity has not been experimentally demonstrated.

Structural links Help

PDB - click here

SCOP: c.1.17.1 , c.1.17.2 , d.41.2.1 , d.41.2.2

CATH: 3.20.140.10

Database links Help

Enzyme: EC:2.4.2.11

Blocks: IPB007229

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR007229

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P39683 Nicotinate phosphoribosyltransferase

Q8CC86 Nicotinate phosphoribosyltransferase

Q8UIS9 Nicotinate phosphoribosyltransferase

Q95XX1 Nicotinate phosphoribosyltransferase

Q9VQX4 Nicotinate phosphoribosyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006406	Nicotinate phosphoribosyltransferase
IPR006405	Nicotinate phosphoribosyltransferase putative
IPR007229	Nicotinate phosphoribosyltransferase-related
IPR015977	Nicotinate phosphoribosyltransferase-like
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Shin DH, Oganesyan N, Jancarik J, Yokota H, Kim R, Kim SH. Crystal structure of a nicotinate phosphoribosyltransferase from Thermoplasma acidophilum. J. Biol. Chem. 280 2005 18326-35 [PubMed: 15753098] http://dx.doi.org/10.1074/jbc.M501622200
	Chappie JS, Canaves JM, Han GW, Rife CL, Xu Q, Stevens RC. The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Structure 13 2005 1385-96 [PubMed: 16154095] http://dx.doi.org/10.1016/j.str.2005.05.016

InterPro 23.1