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InterPro: IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain

Protein matches Help

UniProtKB

Matches:

3665 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR007214 YbaK/aa-tRNA-synth-assoc-dom

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:3.90.960.10	YbaK/aa-tRNA-synth-assoc-reg	2348
Pfam	PF04073	YbaK	3606
SuperFamily	SSF55826	YbaK/aa-tRNA-synth-assoc-reg	3646
Signatures in BioMart

InterPro Relationships Help

Found in

IPR004369 Conserved hypothetical protein CHP00011
IPR004500 Prolyl-tRNA synthetase, class IIa, bacterial
IPR006195 Aminoacyl-tRNA synthetase, class II, conserved region
IPR014627 Uncharacterised conserved protein UCP036888, signal transduction HD-GYP-like, PA5346 type

InterPro annotation

Entry Details in BioMart

Abstract

This domain of unknown function is found in numerous prokaryote organisms. The structure of YbaK shows a novel fold. This domain also occurs in a number of prolyl-tRNA synthetases (proRS) from prokaryotes. Thus, the domain is thought to be involved in oligonucleotide binding, with possible roles in recognition/discrimination or editing of prolyl-tRNA [1].

Structural links Help

PDB - click here

SCOP: d.116.1.1

CATH: 3.90.960.10

Database links Help

Enzyme: EC:6.1.1.15

PANDIT: PF04073

Blocks: IPB007214

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR007214

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A6NEY8 UPF0566 protein

P0AAR3 Uncharacterized protein ybaK

P38708 Putative prolyl-tRNA synthetase YHR020W

P73942 Prolyl-tRNA synthetase

Q9D820 UPF0566 protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017449	Prolyl-tRNA synthetase, class II
IPR004499	Prolyl-tRNA synthetase, class IIa, prokaryotic-type
IPR002316	Prolyl-tRNA synthetase, class IIa, conserved region
IPR004154	Anticodon-binding
IPR007214	YbaK/aminoacyl-tRNA synthetase-associated domain
IPR016061	Prolyl-tRNA synthetase, class II, C-terminal
IPR002314	Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region
IPR004369	Conserved hypothetical protein CHP00011
IPR006195	Aminoacyl-tRNA synthetase, class II, conserved region
IPR004500	Prolyl-tRNA synthetase, class IIa, bacterial
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL

Publications Open in usermanual
1.	Zhang H, Huang K, Li Z, Banerjei L, Fisher KE, Grishin NV, Eisenstein E, Herzberg O. Crystal structure of YbaK protein from Haemophilus influenzae (HI1434) at 1.8 A resolution: functional implications. Proteins 40 86-97 2000 [PubMed: 10813833] http://dx.doi.org/10.1002/(SICI)1097-0134(20000701)40:1<86::AID-PROT100>3.0.CO;2-Y

Additional Reading Help

Murayama K, Kato-Murayama M, Katsura K, Uchikubo-Kamo T, Yamaguchi-Hirafuji M, Kawazoe M, Akasaka R, Hanawa-Suetsugu K, Hori-Takemoto C, Terada T, Shirouzu M, Yokoyama S.
Structure of a putative trans-editing enzyme for prolyl-tRNA synthetase from Aeropyrum pernix K1 at 1.7 A resolution.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 2005 26-9 [PubMed: 16508081]
http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=16508081

InterPro 23.1