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InterPro: IPR007073 RNA polymerase Rpb1, domain 7

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UniProtKB

Matches:

506 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Architectures
Accession List
Matches in BioMart

Accession

IPR007073 RNA_pol_Rpb1_7

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:3.30.1360.90	RNA_pol_Rpb1_7	492
Pfam	PF04990	RNA_pol_Rpb1_7	496
Signatures in BioMart

InterPro Relationships Help

Found in

IPR007081 RNA polymerase Rpb1, domain 5

GO Term annotation Help

Process

GO:0006350 transcription

Function

GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity

InterPro annotation

Entry Details in BioMart

Abstract

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain, domain 7, represents a mobile module of the RNA polymerase. Domain 7 interacts with the lobe domain of Rpb2 (IPR007642) [1, 2].

Structural links Help

PDB - click here

SCOP: e.29.1.2 , i.8.1.1

Database links Help

Enzyme: EC:2.7.7.6

PANDIT: PF04990

Blocks: IPB007073

Taxonomic coverage Help

Example proteins Help

P04050 DNA-directed RNA polymerase II subunit RPB1

P04052 DNA-directed RNA polymerase II subunit RPB1

P08775 DNA-directed RNA polymerase II subunit RPB1

P16356 DNA-directed RNA polymerase II subunit RPB1

P24928 DNA-directed RNA polymerase II subunit RPB1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007083	RNA polymerase Rpb1, domain 4
IPR000684	RNA polymerase II, heptapeptide repeat, eukaryotic
IPR007080	RNA polymerase Rpb1, domain 1
IPR007081	RNA polymerase Rpb1, domain 5
IPR000722	RNA polymerase, alpha subunit
IPR007075	RNA polymerase Rpb1, domain 6
IPR007066	RNA polymerase Rpb1, domain 3
IPR006592	RNA polymerase, N-terminal
IPR007073	RNA polymerase Rpb1, domain 7
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Severinov K, Mustaev A, Kukarin A, Muzzin O, Bass I, Darst SA, Goldfarb A. Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase. J. Biol. Chem. 271 27969-74 1996 [PubMed: 8910400] http://dx.doi.org/10.1074/jbc.271.44.27969
2.	Cramer P, Bushnell DA, Kornberg RD. Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science 292 1863-76 2001 [PubMed: 11313498] http://dx.doi.org/10.1126/science.1059493

Additional Reading Open in usermanual
	Brueckner F, Cramer P. Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation. Nat. Struct. Mol. Biol. 15 2008 811-8 [PubMed: 18552824] http://dx.doi.org/10.1038/nsmb.1458
	Kaplan CD, Larsson KM, Kornberg RD. The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. Mol. Cell 30 2008 547-56 [PubMed: 18538653] http://dx.doi.org/10.1016/j.molcel.2008.04.023
	Brueckner F, Hennecke U, Carell T, Cramer P. CPD damage recognition by transcribing RNA polymerase II. Science 315 2007 859-62 [PubMed: 17290000] http://dx.doi.org/10.1126/science.1135400
	Lehmann E, Brueckner F, Cramer P. Molecular basis of RNA-dependent RNA polymerase II activity. Nature 450 2007 445-9 [PubMed: 18004386] http://dx.doi.org/10.1038/nature06290
	Damsma GE, Alt A, Brueckner F, Carell T, Cramer P. Mechanism of transcriptional stalling at cisplatin-damaged DNA. Nat. Struct. Mol. Biol. 14 2007 1127-33 [PubMed: 17994106] http://dx.doi.org/10.1038/nsmb1314

InterPro 23.1