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InterPro: IPR006952 Retinal cGMP phosphodiesterase, gamma subunit

Protein matches Help

UniProtKB

Matches:

48 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006952 PDE6_gamma

Secondary

IPR011161

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04868	PDE6_gamma	48
PIRSF	PIRSF000969	35-cGMP_Pdiase_g	40
PANTHER	PTHR12122	PDE6_gamma	47
Signatures in BioMart

GO Term annotation Help

Process

GO:0007601 visual perception

Function

GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0030553 cGMP binding

InterPro annotation

Entry Details in BioMart

Abstract

Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit [1], which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells [2].

Structural links Help

PDB - click here

SCOP: j.51.1.1

CATH: 4.10.980.10

Database links Help

Enzyme: EC:3.1.4.17

PANDIT: PF04868

Blocks: IPB006952

Taxonomic coverage Help

Example proteins Help

P04972 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

P09174 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

P18545 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006952	Retinal cGMP phosphodiesterase, gamma subunit
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Muradov KG, Granovsky AE, Schey KL, Artemyev NO. Direct interaction of the inhibitory gamma-subunit of Rod cGMP phosphodiesterase (PDE6) with the PDE6 GAFa domains. Biochemistry 41 3884-90 2002 [PubMed: 11900530] http://dx.doi.org/10.1021/bi015935m
2.	Wan KF, Sambi BS, Frame M, Tate R, Pyne NJ. The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. J. Biol. Chem. 276 37802-8 2001 [PubMed: 11502744] http://intl.jbc.org/cgi/content/full/276/41/37802

Additional Reading Open in usermanual
	Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature 409 2001 1071-7 [PubMed: 11234020] http://dx.doi.org/10.1038/35059138

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