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InterPro: IPR006941 Ribonuclease CAF1

Protein matches Help

UniProtKB

Matches:

489 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006941 RNase_CAF1

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04857	CAF1	489
Signatures in BioMart

InterPro Relationships Help

Parent

IPR012337 Polynucleotidyl transferase, ribonuclease H fold

Contains

IPR001374 Single-stranded nucleic acid binding R3H

GO Term annotation Help

Component

GO:0005634 nucleus

InterPro annotation

Entry Details in BioMart

Abstract

CAF1 is an RNase of the DEDD superfamily, and a subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation. The major pathways of mRNA turnover in eukaryotes initiate with shortening of the poly(A) tail. CAF1 P39008 encodes a critical component of the major cytoplasmic deadenylase in yeast. Caf1p is required for normal mRNA deadenylation in vivo and localises to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent poly(A)-specific exonuclease activity. Some members of this family contain a single-stranded nucleic acid binding domain, R3H.

Structural links Help

PDB - click here

SCOP: c.55.3.9 , d.68.7.1 , g.66.1.1

CATH: 3.30.1370.50 , 3.30.420.10

Database links Help

PANDIT: PF04857

Blocks: IPB006941

Pfam Clan: CL0219.10

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006941

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O64773 Probable CCR4-associated factor 1 homolog 5

O95453 Poly(A)-specific ribonuclease PARN

P39008 Poly(A) ribonuclease POP2

Q17345 CCR4-NOT transcription complex subunit 7

Q8VDG3 Poly(A)-specific ribonuclease PARN

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR014789	Poly(A)-specific ribonuclease, RNA binding
IPR012677	Nucleotide-binding, alpha-beta plait
IPR001374	Single-stranded nucleic acid binding R3H
IPR012337	Polynucleotidyl transferase, ribonuclease H fold
IPR006941	Ribonuclease CAF1
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Tucker M, Valencia-Sanchez MA, Staples RR, Chen J, Denis CL, Parker R. The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell 104 2001 377-86 [PubMed: 11239395] http://dx.doi.org/10.1016/S0092-8674(01)00225-2
	Korner CG, Wormington M, Muckenthaler M, Schneider S, Dehlin E, Wahle E. The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes. EMBO J. 17 1998 5427-37 [PubMed: 9736620] http://dx.doi.org/10.1093/emboj/17.18.5427
	Thore S, Mauxion F, Seraphin B, Suck D. X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex. EMBO Rep. 4 2003 1150-5 [PubMed: 14618157] http://dx.doi.org/10.1038/sj.embor.7400020

InterPro 23.1