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InterPro: IPR006863 Erv1/Alr

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Matches:

418 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Architectures
Accession List
Matches in BioMart

Accession

IPR006863 Evr1_Alr

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:1.20.120.310	Evr1_Alr	358
Pfam	PF04777	Evr1_Alr	407
SuperFamily	SSF69000	Evr1_Alr	406
Signatures in BioMart

InterPro Relationships Help

Parent

IPR017905 ERV/ALR sulphydryl oxidase

GO Term annotation Help

Process

GO:0055114 oxidation reduction

Function

GO:0016972 thiol oxidase activity

InterPro annotation

Entry Details in BioMart

Abstract

Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae (Baker's yeast) mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian ortholog of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane and it is thought to operate downstream of the mitochondrial ABC transporter [1].

Structural links Help

PDB - click here

SCOP: a.24.15.1

CATH: 1.20.120.310

Database links Help

Enzyme: EC:1.8.3.2

PANDIT: PF04777

Blocks: IPB006863

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006863

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O00391 Sulfhydryl oxidase 1

P56213 FAD-linked sulfhydryl oxidase ALR

Q12284 FAD-linked sulfhydryl oxidase ERV2

Q5UP54 Probable FAD-linked sulfhydryl oxidase R596

Q63042 FAD-linked sulfhydryl oxidase ALR

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017936	Thioredoxin-like
IPR013766	Thioredoxin domain
IPR012335	Thioredoxin fold
IPR012336	Thioredoxin-like fold
IPR006863	Erv1/Alr
IPR017905	ERV/ALR sulphydryl oxidase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Lange H, Lisowsky T, Gerber J, Muhlenhoff U, Kispal G, Lill R. An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins. EMBO Rep. 2 715-20 2001 [PubMed: 11493598] http://dx.doi.org/10.1093/embo-reports/kve161

Additional Reading Open in usermanual
	Wu CK, Dailey TA, Dailey HA, Wang BC, Rose JP. The crystal structure of augmenter of liver regeneration: A mammalian FAD-dependent sulfhydryl oxidase. Protein Sci. 12 2003 1109-18 [PubMed: 12717032] http://dx.doi.org/10.1110/ps.0238103
	Vitu E, Bentzur M, Lisowsky T, Kaiser CA, Fass D. Gain of function in an ERV/ALR sulfhydryl oxidase by molecular engineering of the shuttle disulfide. J. Mol. Biol. 362 2006 89-101 [PubMed: 16893552] http://dx.doi.org/10.1016/j.jmb.2006.06.070
	Gross E, Sevier CS, Vala A, Kaiser CA, Fass D. A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p. Nat. Struct. Biol. 9 2002 61-7 [PubMed: 11740506] http://dx.doi.org/10.1038/nsb740

InterPro 23.1