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InterPro: IPR006820 Caudal-like activation domain

Protein matches Help

UniProtKB

Matches:

51 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006820 Caudal_activation_dom

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04731	Caudal_act	51
Signatures in BioMart

InterPro Relationships Help

Found in

IPR015705 Homeobox protein, Cdx

GO Term annotation Help

Process

GO:0007275 multicellular organismal development
GO:0045449 regulation of transcription

Component

GO:0005634 nucleus

InterPro annotation

Entry Details in BioMart

Abstract

This domain occurs at the N-terminal of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 (P43241) is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway [1]. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (IPR001356).

Database links Help

PANDIT: PF04731

Blocks: IPB006820

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006820

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A2T7H5 Homeobox protein CDX-1

O14627 Homeobox protein CDX-4

P18111 Homeobox protein CDX-1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR020479	Homeobox, region
IPR000047	Helix-turn-helix motif, lambda-like repressor
IPR015705	Homeobox protein, Cdx
IPR006820	Caudal-like activation domain
IPR012287	Homeodomain-related
IPR001356	Homeobox
IPR017970	Homeobox, conserved site
IPR009057	Homeodomain-like
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Rings EH, Boudreau F, Taylor JK, Moffett J, Suh ER, Traber PG. Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. Gastroenterology 121 1437-50 2001 [PubMed: 11729123]

InterPro 24.0