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InterPro: IPR006813 Glycosyl transferase, family 17

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129 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR006813 Glyco_trans_17

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04724	Glyco_transf_17	109
PANTHER	PTHR12224	Glyco_trans_17	127
Signatures in BioMart

GO Term annotation Help

Process

GO:0006487 protein amino acid N-linked glycosylation

Function

GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

Component

GO:0016020 membrane

InterPro annotation

Entry Details in BioMart

Abstract

This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, and tumour progression [1, 2].

Database links Help

Enzyme: EC:2.4.1.144

CAZy: GT17

PANDIT: PF04724

Blocks: IPB006813

Taxonomic coverage Help

Example proteins Help

Q02527 Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Q09327 Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Q10470 Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006813	Glycosyl transferase, family 17
	ModBase

Publications Open in usermanual
1.	Bhattacharyya R, Bhaumik M, Raju TS, Stanley P. Truncated, inactive N-acetylglucosaminyltransferase III (GlcNAc-TIII) induces neurological and other traits absent in mice that lack GlcNAc-TIII. J. Biol. Chem. 277 26300-9 2002 [PubMed: 11986323] http://dx.doi.org/10.1074/jbc.M202276200
2.	Ihara H, Ikeda Y, Koyota S, Endo T, Honke K, Taniguchi N. A catalytically inactive beta 1,4-N-acetylglucosaminyltransferase III (GnT-III) behaves as a dominant negative GnT-III inhibitor. Eur. J. Biochem. 269 193-201 2002 [PubMed: 11784313] http://dx.doi.org/10.1046/j.0014-2956.2001.02640.x

InterPro 23.1