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InterPro: IPR006805 Anthranilate synthase component I, N-terminal

Protein matches Help

UniProtKB

Matches:

2443 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006805 Anth_synth_I_N

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04715	Anth_synt_I_N	2443
Signatures in BioMart

InterPro Relationships Help

Found in

IPR005256 Anthranilate synthase component I
IPR005257 Anthranilate synthase component I, TrpE
IPR005801 ADC synthase
IPR005802 Para-aminobenzoate synthase, component I
IPR010112 Anthranilate synthase, clad 3
IPR010116 Anthranilate synthase component I, archaeal
IPR010117 Para-aminobenzoate synthase
IPR010118 Para-aminobenzoate synthase/anthranilate synthase, component I

GO Term annotation Help

Process

GO:0009058 biosynthetic process

Function

GO:0016833 oxo-acid-lyase activity

InterPro annotation

Entry Details in BioMart

Abstract

Anthranilate synthase catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (IPR005801). This region is involved in feedback inhibition by tryptophan [1]. This family also contains a region of Para-aminobenzoate synthase component I.

Structural links Help

PDB - click here

SCOP: d.161.1.1

CATH: 3.60.120.10

Database links Help

Enzyme: EC:4.1.3.27

PANDIT: PF04715

Blocks: IPB006805

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006805

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P00897 Anthranilate synthase component 1

P00899 Anthranilate synthase component 1

P20170 Probable anthranilate synthase component 1

P32068 Anthranilate synthase component I-1, chloroplastic

Q06128 Anthranilate synthase component 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019999	Anthranilate synthase component I, C-terminal
IPR010116	Anthranilate synthase component I, archaeal
IPR006805	Anthranilate synthase component I, N-terminal
IPR005801	ADC synthase
IPR015890	Chorismate binding, C-terminal
IPR005256	Anthranilate synthase component I
IPR005257	Anthranilate synthase component I, TrpE
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE. The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Proc. Natl. Acad. Sci. U.S.A. 98 6021-6 2001 [PubMed: 11371633] http://dx.doi.org/10.1073/pnas.111150298

Additional Reading Open in usermanual
	Morollo AA, Eck MJ. Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium. Nat. Struct. Biol. 8 2001 243-7 [PubMed: 11224570] http://dx.doi.org/10.1038/84988
	Knochel T, Ivens A, Hester G, Gonzalez A, Bauerle R, Wilmanns M, Kirschner K, Jansonius JN. The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications. Proc. Natl. Acad. Sci. U.S.A. 96 1999 9479-84 [PubMed: 10449718] http://dx.doi.org/10.1073/pnas.96.17.9479
	Dosselaere F, Vanderleyden J. A metabolic node in action: chorismate-utilizing enzymes in microorganisms. Crit. Rev. Microbiol. 27 2001 75-131 [PubMed: 11450855]
	Parsons JF, Jensen PY, Pachikara AS, Howard AJ, Eisenstein E, Ladner JE. Structure of Escherichia coli aminodeoxychorismate synthase: architectural conservation and diversity in chorismate-utilizing enzymes. Biochemistry 41 2002 2198-208 [PubMed: 11841211] http://dx.doi.org/10.1021/bi015791b

InterPro 23.1