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InterPro: IPR006674 Metal-dependent phosphohydrolase, HD subdomain

Protein matches Help

UniProtKB

Matches:

13426 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006674 Metal-dep_PHydrolase_HD_sub

Secondary

IPR002819

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01966	HD	13426
Signatures in BioMart

InterPro Relationships Help

Parent

IPR003607 Metal-dependent phosphohydrolase, HD domain

Children

IPR006675 HDIG

Found in

IPR004811 RelA/SpoT protein
IPR006261 Deoxyguanosinetriphosphate triphosphohydrolase
IPR010043 Protein-PII uridylyltransferase
IPR017705 2,3-cyclic-nucleotide 2-phosphodiesterase
IPR017771 Cyanamide hydratase, HD-type
IPR020779 Deoxyguanosinetriphosphate triphosphohydrolase, proteobacteria
IPR020873 3'-5' exoribonuclease YhaM

InterPro annotation

Entry Details in BioMart

Abstract

This domain is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity. These enzymes appear to be involved in the nucleic acid metabolism, signal transduction and possibly other functions in bacteria, archaea and eukaryotes. The fact that all the highly conserved residues in the HD superfamily are histidines or aspartates suggests that coordination of divalent cations is essential for the activity of these proteins [1].

Structural links Help

PDB - click here

SCOP: a.211.1.1

CATH: 1.10.3210.10 , 1.10.472.50

Database links Help

PANDIT: PF01966

Blocks: IPB006674

Pfam Clan: CL0237.4

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006674

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P38331 HD domain-containing protein YBR242W

P54371 Uncharacterized protein slr0104

Q09374 Uncharacterized protein ZK177.8

Q3SXD3 HD domain-containing protein 2

Q9Y3Z3 SAM domain and HD domain-containing protein 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011510	Sterile alpha motif homology 2
IPR001660	Sterile alpha motif SAM
IPR006675	HDIG
IPR006674	Metal-dependent phosphohydrolase, HD subdomain
IPR011624	Metal-dependent phosphohydrolase, 7TM extracellular domain
IPR010993	Sterile alpha motif homology
IPR011621	Metal-dependent phosphohydrolase, 7TM intracellular domain
IPR003607	Metal-dependent phosphohydrolase, HD domain
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Aravind L, Koonin EV. The HD domain defines a new superfamily of metal-dependent phosphohydrolases. Trends Biochem. Sci. 23 469-72 1998 [PubMed: 9868367] http://dx.doi.org/10.1016/S0968-0004(98)01293-6

Additional Reading Open in usermanual
	Hogg T, Mechold U, Malke H, Cashel M, Hilgenfeld R. Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected]. Cell 117 2004 57-68 [PubMed: 15066282] http://dx.doi.org/10.1016/S0092-8674(04)00260-0
	Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH. Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 2007 369-74 [PubMed: 17565173]
	Zimmerman MD, Proudfoot M, Yakunin A, Minor W. Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli. J. Mol. Biol. 378 2008 215-26 [PubMed: 18353368] http://dx.doi.org/10.1016/j.jmb.2008.02.036

InterPro 23.1