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InterPro: IPR006620 Prolyl 4-hydroxylase, alpha subunit

Protein matches Help

UniProtKB

Matches:

2234 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006620 Pro_4_hyd_alph

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SMART	SM00702	P4Hc	2234
Signatures in BioMart

InterPro Relationships Help

Parent

IPR005123 Oxoglutarate/iron-dependent oxygenase

Found in

IPR001006 Procollagen-lysine 5-dioxygenase

GO Term annotation Help

Process

GO:0055114 oxidation reduction

Function

GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

InterPro annotation

Entry Details in BioMart

Abstract

Mammalian prolyl 4-hydroxylase alpha catalyses the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly-sequences in collagens and other proteins. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor [1].

Database links Help

Enzyme: EC:1.14.11

Blocks: IPB006620

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006620

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P13674 Prolyl 4-hydroxylase subunit alpha-1

P40032 PKHD-type hydroxylase TPA1

Q10576 Prolyl 4-hydroxylase subunit alpha-1

Q3ED68 Uncharacterized PKHD-type hydroxylase At1g22950

Q3U0K8 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR005123	Oxoglutarate/iron-dependent oxygenase
IPR011990	Tetratricopeptide-like helical
IPR013026	Tetratricopeptide repeat-containing domain
IPR019601	Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain
IPR019734	Tetratricopeptide repeat
IPR013547	Prolyl 4-hydroxylase alpha-subunit, N-terminal
IPR006620	Prolyl 4-hydroxylase, alpha subunit
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Aravind L, Koonin EV. The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol. 2 RESEARCH0007 2001 [PubMed: 11276424] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=11276424

InterPro 23.1