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InterPro: IPR006597 Sel1-like

Protein matches Help

UniProtKB

Matches:

4575 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006597 Sel1-like

Secondary

IPR013245

Type

Repeat

Signatures Help

Database	ID	Name	Proteins
Pfam	PF08238	Sel1	4029
SMART	SM00671	SEL1	4378
Signatures in BioMart

InterPro Relationships Help

Found in

IPR011990 Tetratricopeptide-like helical
IPR017400 Elongation factor 2 kinase

InterPro annotation

Entry Details in BioMart

Abstract

Sel1-like repeats are tetratricopeptide repeat sequences originally identified in a Caenorhabditis elegans receptor molecule which is a key negative regulator of the Notch pathway [1]. Mammalian homologues have since been identified although these mainly pancreatic proteins have yet to have a function assigned.

Structural links Help

PDB - click here

SCOP: a.118.18.1

CATH: 1.25.40.10

Database links Help

Blocks: IPB006597

Pfam Clan: CL0020.21

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006597

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A6ZR53 Protein SHC1

O00418 Elongation factor 2 kinase

O01991 Elongation factor 2 kinase

O08796 Elongation factor 2 kinase

Q9W5N0 Hcp beta-lactamase-like protein CG13865

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011009	Protein kinase-like domain
IPR004166	MHCK/EF2 kinase
IPR011990	Tetratricopeptide-like helical
IPR006597	Sel1-like
IPR017400	Elongation factor 2 kinase
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Grant B, Greenwald I. The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein. Genetics 143 237-47 1996 [PubMed: 8722778] http://intl.genetics.org/cgi/content/abstract/143/1/237

Additional Reading Open in usermanual
	Luthy L, Grutter MG, Mittl PR. The crystal structure of Helicobacter cysteine-rich protein C at 2.0 A resolution: similar peptide-binding sites in TPR and SEL1-like repeat proteins. J. Mol. Biol. 340 2004 829-41 [PubMed: 15223324] http://dx.doi.org/10.1016/j.jmb.2004.04.055
	Luthy L, Grutter MG, Mittl PR. The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein. J. Biol. Chem. 277 2002 10187-93 [PubMed: 11777911] http://dx.doi.org/10.1074/jbc.M108993200

InterPro 23.1