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InterPro: IPR006592 RNA polymerase, N-terminal

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UniProtKB

Matches:

5696 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006592 RNA_pol_N

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SMART	SM00663	RPOLA_N	5696
Signatures in BioMart

InterPro Relationships Help

Found in

IPR012754 DNA-directed RNA polymerase, subunit beta-prime
IPR012755 DNA-directed RNA polymerase, subunit gamma
IPR012758 DNA-directed RNA polymerase, subunit A'
IPR015699 DNA-directed RNA pol I, largest subunit
IPR015700 DNA-directed RNA polymerase III largest subunit

Contains

IPR000722 RNA polymerase, alpha subunit

GO Term annotation Help

Process

GO:0006350 transcription

Function

GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity

InterPro annotation

Entry Details in BioMart

Abstract

The task of transcribing nuclear genes is shared between three RNA polymerases in eukaryotes: RNA polymerase (pol) I synthesizes the large rRNA, pol II synthesizes mRNA and pol III synthesizes tRNA and 5S rRNA [1]. Pol I transcription is localised to discrete sites called nucleoli; these can be likened to ribosome factories, in which rRNA is synthesised by pol I in the fibrillar centres and then processed and assembled into ribosomes in the surrounding granular regions [2]. Prokaryotes, in contrast, posses a single RNA polymerase, with transcription being controlled by the particular signam factor interacting with the catalytic core.

This entry describes an N-terminal conserved region which can be found in the largest subunits of prokaryoptic and eukaryotic RNA polymerases.

Structural links Help

PDB - click here

SCOP: e.29.1.2 , i.8.1.1

Database links Help

Enzyme: EC:2.7.7.6

Blocks: IPB006592

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006592

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O14802 DNA-directed RNA polymerase III subunit RPC1

O35134 DNA-directed RNA polymerase I subunit RPA1

P04050 DNA-directed RNA polymerase II subunit RPB1

P04052 DNA-directed RNA polymerase II subunit RPB1

P16356 DNA-directed RNA polymerase II subunit RPB1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007083	RNA polymerase Rpb1, domain 4
IPR007080	RNA polymerase Rpb1, domain 1
IPR007081	RNA polymerase Rpb1, domain 5
IPR015699	DNA-directed RNA pol I, largest subunit
IPR006592	RNA polymerase, N-terminal
IPR000684	RNA polymerase II, heptapeptide repeat, eukaryotic
IPR000722	RNA polymerase, alpha subunit
IPR007066	RNA polymerase Rpb1, domain 3
IPR007075	RNA polymerase Rpb1, domain 6
IPR007073	RNA polymerase Rpb1, domain 7
	PDB Chain
	ModBase
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Paule MR, White RJ. Survey and summary: transcription by RNA polymerases I and III. Nucleic Acids Res. 28 1283-98 2000 [PubMed: 10684922] http://dx.doi.org/10.1093/nar/28.6.1283
2.	Shaw PJ, Jordan EG. The nucleolus. Annu. Rev. Cell Dev. Biol. 11 93-121 1995 [PubMed: 8689574] http://dx.doi.org/10.1146/annurev.cb.11.110195.000521

Additional Reading Open in usermanual
	Vassylyev DG, Vassylyeva MN, Zhang J, Palangat M, Artsimovitch I, Landick R. Structural basis for substrate loading in bacterial RNA polymerase. Nature 448 2007 163-8 [PubMed: 17581591] http://dx.doi.org/10.1038/nature05931
	Brueckner F, Cramer P. Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation. Nat. Struct. Mol. Biol. 15 2008 811-8 [PubMed: 18552824] http://dx.doi.org/10.1038/nsmb.1458
	Kaplan CD, Larsson KM, Kornberg RD. The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. Mol. Cell 30 2008 547-56 [PubMed: 18538653] http://dx.doi.org/10.1016/j.molcel.2008.04.023
	Brueckner F, Hennecke U, Carell T, Cramer P. CPD damage recognition by transcribing RNA polymerase II. Science 315 2007 859-62 [PubMed: 17290000] http://dx.doi.org/10.1126/science.1135400
	Mukhopadhyay J, Das K, Ismail S, Koppstein D, Jang M, Hudson B, Sarafianos S, Tuske S, Patel J, Jansen R, Irschik H, Arnold E, Ebright RH. The RNA polymerase "switch region" is a target for inhibitors. Cell 135 2008 295-307 [PubMed: 18957204] http://dx.doi.org/10.1016/j.cell.2008.09.033

InterPro 23.1