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InterPro: IPR006426 Asparagine synthase, glutamine-hydrolyzing

Protein matches Help

UniProtKB

Matches:

1777 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006426 Asn_synth_AEB

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01536	asn_synth_AEB	1777
Signatures in BioMart

InterPro Relationships Help

Children

IPR017535 Asparagine synthase family amidotransferase
IPR017539 Exosortase 1 system-associated amidotransferase 1

Contains

IPR000583 Glutamine amidotransferase, class-II
IPR001962 Asparagine synthase
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

GO Term annotation Help

Process

GO:0006529 asparagine biosynthetic process

Function

GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity

InterPro annotation

Entry Details in BioMart

Abstract

These sequences represent glutamine-hydrolysing asparagine synthase. The group have a poorly conserved C-terminal extension while bacterial members of the family tend to have a long, poorly conserved insert lacking from archaeal and eukaryotic sequences. Multiple isozymes have been demonstrated, such as in Bacillus subtilis [1].

Structural links Help

PDB - click here

SCOP: c.26.2.1 , d.153.1.1

CATH: 3.40.50.620 , 3.60.20.10

Database links Help

Enzyme: EC:6.3.5.4

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006426

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P08243 Asparagine synthetase [glutamine-hydrolyzing]

P49078 Asparagine synthetase [glutamine-hydrolyzing]

P49089 Asparagine synthetase [glutamine-hydrolyzing] 1

Q43011 Asparagine synthetase [glutamine-hydrolyzing]

Q61024 Asparagine synthetase [glutamine-hydrolyzing]

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000583	Glutamine amidotransferase, class-II
IPR006426	Asparagine synthase, glutamine-hydrolyzing
IPR001962	Asparagine synthase
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
IPR017932	Glutamine amidotransferase, type II
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Yoshida K, Fujita Y, Ehrlich SD. Three asparagine synthetase genes of Bacillus subtilis. J. Bacteriol. 181 6081-91 1999 [PubMed: 10498721] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=10498721&action=stream&blobtype=pdf

Additional Reading Open in usermanual
	Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product. Biochemistry 38 1999 16146-57 [PubMed: 10587437] http://dx.doi.org/10.1021/bi9915768

InterPro 23.1