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InterPro: IPR006407 1,4-alpha-glucan branching enzyme, core region

Protein matches Help

UniProtKB

Matches:

1071 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006407 1-4-A-glucan_branch_enz_core

Type

Region

Signatures Help

Database	ID	Name	Proteins
HAMAP	MF_00685	1-4-A-glucan_branch_enz_core	817
TIGRFAMs	TIGR01515	branching_enzym	1071
Signatures in BioMart

InterPro Relationships Help

Contains

IPR004193 Glycoside hydrolase, family 13, N-terminal
IPR006047 Glycosyl hydrolase, family 13, catalytic domain
IPR006048 Alpha-amylase, C-terminal all beta
IPR013781 Glycoside hydrolase, subgroup, catalytic core
IPR013783 Immunoglobulin-like fold
IPR014756 Immunoglobulin E-set
IPR015902 Alpha Amylase
IPR017853 Glycoside hydrolase, catalytic core

GO Term annotation Help

Process

GO:0005978 glycogen biosynthetic process

Function

GO:0003844 1,4-alpha-glucan branching enzyme activity

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents the core region of the glycogen branching enzymes, which are responsible for the transfer of chains of approximately seven alpha(1,4)-linked glucosyl residues to other similar chains (in new alpha-(1,6) linkages) in the biosynthesis of glycogen [1]. The branching enzyme is responsible for the degree of alpha(1,6) branch linkages found in polysaccharides [2].

Structural links Help

PDB - click here

SCOP: b.1.18.2 , b.71.1.1 , c.1.8.1

CATH: 2.60.40.10 , 2.60.40.1180 , 3.20.20.80

Database links Help

Enzyme: EC:2.4.1.18

CluSTr: ALLvsALL:36061:94.3

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006407

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A2BQ65 1,4-alpha-glucan-branching enzyme

P07762 1,4-alpha-glucan-branching enzyme

P52981 1,4-alpha-glucan-branching enzyme

Q6L2Z9 1,4-alpha-glucan-branching enzyme

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR013780	Glycosyl hydrolase, family 13, all-beta
IPR013783	Immunoglobulin-like fold
IPR006047	Glycosyl hydrolase, family 13, catalytic domain
IPR006048	Alpha-amylase, C-terminal all beta
IPR014756	Immunoglobulin E-set
IPR004193	Glycoside hydrolase, family 13, N-terminal
IPR006407	1,4-alpha-glucan branching enzyme, core region
IPR017853	Glycoside hydrolase, catalytic core
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Guan H, Kuriki T, Sivak M, Preiss J. Maize branching enzyme catalyzes synthesis of glycogen-like polysaccharide in glgB-deficient Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 92 964-7 1995 [PubMed: 7862674] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=7862674
2.	Tolmasky DS, Krisman CR. The degree of branching in (alpha 1,4)-(alpha 1,6)-linked glucopolysaccharides is dependent on intrinsic properties of the branching enzymes. Eur. J. Biochem. 168 393-7 1987 [PubMed: 2959476] http://dx.doi.org/10.1111/j.1432-1033.1987.tb13432.x

Additional Reading Open in usermanual
	Libessart N, Preiss J. High-level expression of branching enzyme II from maize endosperm in Escherichia coli. Protein Expr. Purif. 14 1998 1-7 [PubMed: 9758744] http://dx.doi.org/10.1006/prep.1998.0950
	MacGregor EA, Janecek S, Svensson B. Relationship of sequence and structure to specificity in the alpha-amylase family of enzymes. Biochim. Biophys. Acta 1546 2001 1-20 [PubMed: 11257505] http://dx.doi.org/10.1016/S0167-4838(00)00302-2
	Abad MC, Binderup K, Rios-Steiner J, Arni RK, Preiss J, Geiger JH. The X-ray crystallographic structure of Escherichia coli branching enzyme. J. Biol. Chem. 277 2002 42164-70 [PubMed: 12196524] http://dx.doi.org/10.1074/jbc.M205746200

InterPro 23.1