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InterPro: IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like

Protein matches Help

UniProtKB

Matches:

2346 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006383 HAD-SF_hydro_IB_PSP-like

Type

Domain

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01488	HAD-SF-IB	2346
Signatures in BioMart

InterPro Relationships Help

Children

IPR004469 Phosphoserine phosphatase SerB
IPR006385 HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial

Found in

IPR006384 Pyridoxal phosphate phosphatase-related
IPR006386 HAD-superfamily hydrolase, subfamily IB, PSPase-like, archaeal
IPR016965 Pyridoxal phosphate phosphatase, PHOSPHO2
IPR017718 HAD-superfamily hydrolase, subfamily IB, MtnX

GO Term annotation Help

Process

GO:0008152 metabolic process

Function

GO:0016791 phosphatase activity

InterPro annotation

Entry Details in BioMart

Abstract

This group represents a subfamily of the haloacid dehalogenase superfamily of aspartate-nucleophile hydrolases. Subfamily IA, B, C and D are distinguished from the rest of the superfamily by the presence of a variable domain between the first and second conserved catalytic motifs. In subfamilies IA and IB, this domain consists of an alpha-helical bundle. It was necessary to model these two subfamilies separately, breaking them at an apparent phylogenetic bifurcation, so that the resulting model(s) are not so broadly defined that members of subfamily III (which lack the variable domain) are included.

Structural links Help

PDB - click here

SCOP: c.108.1.20 , c.108.1.4

CATH: 1.10.150.210 , 3.40.50.1000

Database links Help

Enzyme: EC:3.1.3

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006383

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O82796 Phosphoserine phosphatase, chloroplastic

P42941 Phosphoserine phosphatase

P78330 Phosphoserine phosphatase

Q8R2H9 Phosphoethanolamine/phosphocholine phosphatase

Q9VSY6 Phosphoserine phosphatase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR005834	Haloacid dehalogenase-like hydrolase
IPR004469	Phosphoserine phosphatase SerB
IPR006383	HAD-superfamily hydrolase, subfamily IB, PSPase-like
IPR016965	Pyridoxal phosphate phosphatase, PHOSPHO2
IPR006384	Pyridoxal phosphate phosphatase-related
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY. Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. J. Biol. Chem. 277 2002 46651-8 [PubMed: 12213811] http://dx.doi.org/10.1074/jbc.M204866200
	Xu Q, Saikatendu KS, Krishna SS, McMullan D, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Elsliger MA, Feuerhelm J, Grzechnik SK, Hale J, Hampton E, Han GW, Haugen J, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Koesema E, Miller MD, Morse AT, Nigoghossian E, Okach L, Oommachen S, Paulsen J, Reyes R, Rife CL, Schwarzenbacher R, van den Bedem H, White A, Wolf G, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA. Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 angstroms resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate. Proteins 69 2007 433-9 [PubMed: 17654724] http://dx.doi.org/10.1002/prot.21602
	Peeraer Y, Rabijns A, Verboven C, Collet JF, Van Schaftingen E, De Ranter C. High-resolution structure of human phosphoserine phosphatase in open conformation. Acta Crystallogr. D Biol. Crystallogr. 59 2003 971-7 [PubMed: 12777757] http://dx.doi.org/10.1107/S0907444903005407
	Wang W, Kim R, Jancarik J, Yokota H, Kim SH. Crystal structure of phosphoserine phosphatase from Methanococcus jannaschii, a hyperthermophile, at 1.8 A resolution. Structure 9 2001 65-71 [PubMed: 11342136] http://dx.doi.org/10.1016/S0969-2126(00)00558-X
	Wang W, Cho HS, Kim R, Jancarik J, Yokota H, Nguyen HH, Grigoriev IV, Wemmer DE, Kim SH. Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic "snapshots" of intermediate states. J. Mol. Biol. 319 2002 421-31 [PubMed: 12051918] http://dx.doi.org/10.1016/S0022-2836(02)00324-8

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