Members of this group are characterised by two well-conserved short regions separated by a variable region in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterised as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548 [1].
Motamedi H, Shafiee A, Cai SJ, Streicher SL, Arison BH, Miller RR.
Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.
J. Bacteriol. 178 5243-8 1996
[PubMed: 8752344] http://jb.asm.org/cgi/content/abstract/178/17/5243
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