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InterPro: IPR006281 Sarcosine oxidase, monomeric

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UniProtKB

Matches:

24 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006281 SoxA_mon

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01377	soxA_mon	24
Signatures in BioMart

InterPro Relationships Help

Contains

IPR006076 FAD dependent oxidoreductase

GO Term annotation Help

Process

GO:0046653 tetrahydrofolate metabolic process
GO:0055114 oxidation reduction

Function

GO:0008115 sarcosine oxidase activity

InterPro annotation

Entry Details in BioMart

Abstract

This set of sequences describe the alpha subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Rhizobium loti (Mesorhizobium loti) and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members share the same function. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate [1].

Bacterial sarcosine oxidases have been isolated from over a dozen different organisms and fall into two major classes (1) monomeric form that contains only covalent flavin and (2) heterotetrameric (alpha, beta, gamma, delta) form that contain a covalent and noncovalent flavin, this entry represents the monomeric form.

Structural links Help

PDB - click here

SCOP: c.3.1.2 , d.16.1.3

CATH: 3.30.9.10 , 3.50.50.60

Database links Help

Enzyme: EC:1.5.3.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006281

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P23342 Monomeric sarcosine oxidase

P79371 Peroxisomal sarcosine oxidase

Q9D826 Peroxisomal sarcosine oxidase

Q9P0Z9 Peroxisomal sarcosine oxidase

Q9SJA7 Probable sarcosine oxidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006281	Sarcosine oxidase, monomeric
IPR006076	FAD dependent oxidoreductase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain

Publications Open in usermanual
1.	Kvalnes-Krick K, Jorns MS. Bacterial sarcosine oxidase: comparison of two multisubunit enzymes containing both covalent and noncovalent flavin. Biochemistry 25 6061-9 1986 [PubMed: 3790506] http://dx.doi.org/10.1021/bi00368a034

Additional Reading Open in usermanual
	Zhao G, Song H, Chen ZW, Mathews FS, Jorns MS. Monomeric sarcosine oxidase: role of histidine 269 in catalysis. Biochemistry 41 2002 9751-64 [PubMed: 12146941] http://dx.doi.org/10.1021/bi020286f
	Trickey P, Wagner MA, Jorns MS, Mathews FS. Monomeric sarcosine oxidase: structure of a covalently flavinylated amine oxidizing enzyme. Structure 7 1999 331-45 [PubMed: 10368302] http://dx.doi.org/10.1016/S0969-2126(99)80043-4
	Wagner MA, Trickey P, Chen ZW, Mathews FS, Jorns MS. Monomeric sarcosine oxidase: 1. Flavin reactivity and active site binding determinants. Biochemistry 39 2000 8813-24 [PubMed: 10913292] http://dx.doi.org/10.1021/bi000349z
	Hassan-Abdallah A, Zhao G, Chen ZW, Mathews FS, Schuman Jorns M. Arginine 49 is a bifunctional residue important in catalysis and biosynthesis of monomeric sarcosine oxidase: a context-sensitive model for the electrostatic impact of arginine to lysine mutations. Biochemistry 47 2008 2913-22 [PubMed: 18251505] http://dx.doi.org/10.1021/bi702351v
	Chen ZW, Zhao G, Martinovic S, Jorns MS, Mathews FS. Structure of the sodium borohydride-reduced N-(cyclopropyl)glycine adduct of the flavoenzyme monomeric sarcosine oxidase. Biochemistry 44 2005 15444-50 [PubMed: 16300392] http://dx.doi.org/10.1021/bi0515422

InterPro 23.1