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InterPro: IPR006276 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase

Protein matches Help

UniProtKB

Matches:

934 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006276 MeTrfase_B12_ind

Type

Family

Signatures Help

Database	ID	Name	Proteins
HAMAP	MF_00172	MeTrfase_B12_ind	754
PIRSF	PIRSF000382	MeTrfase_B12_ind	921
TIGRFAMs	TIGR01371	met_syn_B12ind	922
Signatures in BioMart

InterPro Relationships Help

Contains

IPR002629 Methionine synthase, vitamin-B12 independent
IPR013215 Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal

GO Term annotation Help

Process

GO:0009086 methionine biosynthetic process

Function

GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

This group represents cobalamin-independent methionine synthase. A family of uncharacterised archaeal proteins having substantial homology to the C-terminal region of this family, are not included in this group, though they are contained in a larger family of vitamin-B12 independent methionine synthase.

Structural links Help

PDB - click here

SCOP: c.1.22.2

CATH: 3.20.20.210

Database links Help

Enzyme: EC:2.1.1.14

CluSTr: ALLvsALL:2987:40.6

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006276

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O50008 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

P05694 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

P82610 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Q117R7 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Q8CWX6 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013215	Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal
IPR006276	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
IPR002629	Methionine synthase, vitamin-B12 independent
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Koutmos M, Pejchal R, Bomer TM, Matthews RG, Smith JL, Ludwig ML. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc. Natl. Acad. Sci. U.S.A. 105 2008 3286-91 [PubMed: 18296644] http://dx.doi.org/10.1073/pnas.0709960105
	Pejchal R, Ludwig ML. Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication. PLoS Biol. 3 2005 e31 [PubMed: 15630480] http://dx.doi.org/10.1371/journal.pbio.0030031
	Ferrer JL, Ravanel S, Robert M, Dumas R. Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate. J. Biol. Chem. 279 2004 44235-8 [PubMed: 15326182] http://dx.doi.org/10.1074/jbc.C400325200

InterPro 23.1