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InterPro: IPR006222 Glycine cleavage T-protein, N-terminal

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UniProtKB

Matches:

3495 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006222 GCV_T_N

Secondary

IPR002536

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01571	GCV_T	3495
Signatures in BioMart

InterPro Relationships Help

Found in

IPR006223 Glycine cleavage system T protein
IPR006277 Sarcosine oxidase, alpha subunit, heterotetrameric

GO Term annotation Help

Process

GO:0006546 glycine catabolic process

Function

GO:0004047 aminomethyltransferase activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase EC:2.1.2.10 that catalyses the following reaction:

(6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH₃ + dihydrolipoylprotein

Structural links Help

PDB - click here

SCOP: d.250.1.1

Database links Help

PANDIT: PF01571

Blocks: IPB006222

Pfam Clan: CL0289.2

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006222

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O65396 Aminomethyltransferase, mitochondrial

P48015 Aminomethyltransferase, mitochondrial

P48728 Aminomethyltransferase, mitochondrial

P54261 Aminomethyltransferase

Q7TSQ8 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006076	FAD dependent oxidoreductase
IPR006223	Glycine cleavage system T protein
IPR013977	Glycine cleavage T-protein, C-terminal barrel
IPR006222	Glycine cleavage T-protein, N-terminal
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

Additional Reading Open in usermanual
	Lee HH, Kim DJ, Ahn HJ, Ha JY, Suh SW. Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia. J. Biol. Chem. 279 2004 50514-23 [PubMed: 15355973] http://dx.doi.org/10.1074/jbc.M409672200
	Leys D, Basran J, Scrutton NS. Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase. EMBO J. 22 2003 4038-48 [PubMed: 12912903] http://dx.doi.org/10.1093/emboj/cdg395
	McNeil JB, Zhang F, Taylor BV, Sinclair DA, Pearlman RE, Bognar AL. Cloning, and molecular characterization of the GCV1 gene encoding the glycine cleavage T-protein from Saccharomyces cerevisiae. Gene 186 1997 13-20 [PubMed: 9047339] http://dx.doi.org/10.1016/S0378-1119(96)00670-1
	Lokanath NK, Kuroishi C, Okazaki N, Kunishima N. Crystal structure of a component of glycine cleavage system: T-protein from Pyrococcus horikoshii OT3 at 1.5 A resolution. Proteins 58 2005 769-73 [PubMed: 15609340] http://dx.doi.org/10.1002/prot.20345
	Teplyakov A, Obmolova G, Sarikaya E, Pullalarevu S, Krajewski W, Galkin A, Howard AJ, Herzberg O, Gilliland GL. Crystal structure of the YgfZ protein from Escherichia coli suggests a folate-dependent regulatory role in one-carbon metabolism. J. Bacteriol. 186 2004 7134-40 [PubMed: 15489424] http://dx.doi.org/10.1128/JB.186.21.7134-7140.2004

InterPro 23.1