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InterPro: IPR006221 Glutamine amidotransferase of anthranilate synthase

Protein matches Help

UniProtKB

Matches:

2222 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006221 TrpG_papA

Secondary

IPR002385

Type

Domain

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00566	trpG_papA	2222
Signatures in BioMart

InterPro Relationships Help

Parent

IPR006220 Anthranilate synthase component II/delta crystallin

Found in

IPR010112 Anthranilate synthase, clad 3
IPR010117 Para-aminobenzoate synthase
IPR016302 Anthranilate synthase, component II, fungi

GO Term annotation Help

Process

GO:0008152 metabolic process

Function

GO:0004049 anthranilate synthase activity

InterPro annotation

Entry Details in BioMart

Abstract

This entry presents the glutamine amidotransferase domain or peptide of the tryptophan-biosynthetic pathway enzyme anthranilate synthase or of the folate biosynthetic pathway enzyme para-aminobenzoate synthase. In at least one case, a single polypeptide from Bacillus subtilis was shown to have both functions.

Structural links Help

PDB - click here

SCOP: c.23.16.1

CATH: 3.40.50.880

Database links Help

Enzyme: EC:4.1.3.27

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006221

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O19914 Anthranilate synthase component II

O94277 Putative aminodeoxychorismate synthase

P00900 Anthranilate synthase component II

P00937 Anthranilate synthase component 2

Q06129 Anthranilate synthase component II

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013785	Aldolase-type TIM barrel
IPR011702	Glutamine amidotransferase superfamily
IPR013798	Indole-3-glycerol phosphate synthase
IPR005801	ADC synthase
IPR006805	Anthranilate synthase component I, N-terminal
IPR017926	Glutamine amidotransferase type 1
IPR006221	Glutamine amidotransferase of anthranilate synthase
IPR006220	Anthranilate synthase component II/delta crystallin
IPR001468	Indole-3-glycerol phosphate synthase, central region
IPR000991	Glutamine amidotransferase class-I, C-terminal
IPR010117	Para-aminobenzoate synthase
IPR011060	Ribulose-phosphate binding barrel
IPR015890	Chorismate binding, C-terminal
IPR001317	Carbamoyl phosphate synthase, GATase domain
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Morollo AA, Eck MJ. Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium. Nat. Struct. Biol. 8 2001 243-7 [PubMed: 11224570] http://dx.doi.org/10.1038/84988
	Knochel T, Ivens A, Hester G, Gonzalez A, Bauerle R, Wilmanns M, Kirschner K, Jansonius JN. The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications. Proc. Natl. Acad. Sci. U.S.A. 96 1999 9479-84 [PubMed: 10449718] http://dx.doi.org/10.1073/pnas.96.17.9479
	Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE. The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Proc. Natl. Acad. Sci. U.S.A. 98 2001 6021-6 [PubMed: 11371633] http://dx.doi.org/10.1073/pnas.111150298

InterPro 23.1