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InterPro: IPR006204 GHMP kinase

Protein matches Help

UniProtKB

Matches:

5890 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR006204 GHMP_kinase

Secondary

IPR001745

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00288	GHMP_kinases_N	5890
Signatures in BioMart

InterPro Relationships Help

Found in

IPR000705 Galactokinase
IPR000870 Homoserine kinase
IPR001174 Galactokinase/homoserine kinase
IPR004422 GHMP kinase group 1
IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
IPR005916 Phosphomevalonate kinase, eukaryotic
IPR005917 Phosphomevalonate kinase, Gram-positive
IPR005935 Diphosphomevalonate decarboxylase
IPR006205 Mevalonate kinase
IPR006206 Mevalonate/galactokinase
IPR010189 Shikimate kinase, archaea
IPR012043 GHMP kinase-like, archaeal
IPR012363 Propanediol utilisation/coumermycin biosynthesis, PduX-related
IPR012369 Galactokinase, glycosyltransferase
IPR014606 D,D-heptose 7-phosphate kinase
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
IPR016005 Phosphomevalonate kinase, ERG8
IPR020568 Ribosomal protein S5 domain 2-type fold

Contains

IPR006203 GHMP kinase, ATP-binding, conserved site

GO Term annotation Help

Process

GO:0016310 phosphorylation

Function

GO:0005524 ATP binding
GO:0016301 kinase activity

InterPro annotation

Entry Details in BioMart

Abstract

The galacto- (EC:2.7.1.6), homoserine (EC:2.7.1.39), mevalonate (EC:2.7.1.36) and phosphomevalonate (EC:2.7.4.2) kinases contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP [1, 2]. This group of kinases has been called 'GHMP' (from the first letter of their substrates).

Structural links Help

PDB - click here

SCOP: d.14.1.5

CATH: 3.30.230.10

Database links Help

Enzyme: EC:2.7.1

PANDIT: PF00288

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR006204

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O81014 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic

P04385 Galactokinase

P51570 Galactokinase

P72663 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Q99JF5 Diphosphomevalonate decarboxylase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR020568	Ribosomal protein S5 domain 2-type fold
IPR019741	Galactokinase, conserved site
IPR006206	Mevalonate/galactokinase
IPR006203	GHMP kinase, ATP-binding, conserved site
IPR006204	GHMP kinase
IPR013750	GHMP kinase, C-terminal
IPR005935	Diphosphomevalonate decarboxylase
IPR000705	Galactokinase
IPR014721	Ribosomal protein S5 domain 2-type fold, subgroup
IPR004424	4-diphosphocytidyl-2C-methyl-D-erythritol kinase
IPR019539	Galactokinase galactose-binding domain
	PDB Chain
	ModBase
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Tsay YH, Robinson GW. Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. Mol. Cell. Biol. 11 620-31 1991 [PubMed: 1846667] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=1846667
2.	Lee M, Leustek T. Identification of the gene encoding homoserine kinase from Arabidopsis thaliana and characterization of the recombinant enzyme derived from the gene. Arch. Biochem. Biophys. 372 135-42 1999 [PubMed: 10562426] http://dx.doi.org/10.1006/abbi.1999.1481

Additional Reading Open in usermanual
	Fu Z, Voynova NE, Herdendorf TJ, Miziorko HM, Kim JJ. Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry 47 2008 3715-24 [PubMed: 18302342] http://dx.doi.org/10.1021/bi7024386
	Byres E, Alphey MS, Smith TK, Hunter WN. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. J. Mol. Biol. 371 2007 540-53 [PubMed: 17583736] http://dx.doi.org/10.1016/j.jmb.2007.05.094
	Byres E, Martin DM, Hunter WN. A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 2005 581-4 [PubMed: 16511101]
	Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ. Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins 60 2005 787-96 [PubMed: 16021622] http://dx.doi.org/10.1002/prot.20541
	Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactokinase: implications for type II galactosemia. J. Biol. Chem. 280 2005 9662-70 [PubMed: 15590630] http://dx.doi.org/10.1074/jbc.M412916200

InterPro 23.1