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InterPro: IPR005993 Guanosine monophosphate reductase 1

Protein matches Help

UniProtKB

Matches:

241 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005993 GMP_reduct1

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF000235	GMP_reductase	238
TIGRFAMs	TIGR01305	GMP_reduct_1	232
Signatures in BioMart

InterPro Relationships Help

Parent

IPR001093 IMP dehydrogenase/GMP reductase

Contains

IPR015875 IMP dehydrogenase / GMP reductase, conserved site

GO Term annotation Help

Process

GO:0009117 nucleotide metabolic process
GO:0055114 oxidation reduction

Function

GO:0003920 GMP reductase activity

InterPro annotation

Entry Details in BioMart

Abstract

Guanosine monophosphate reductase (EC:1.7.1.7) catalyzes the irreversible and NADPH-dependent reductive deamination of GMP into IMP.

NADPH + guanosine 5-phosphate = NADP+ + inosine 5-phosphate + NH3

It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides. A deep split separates two families of GMP reductase. This family includes both eukaryotic and some proteobacterial sequences.

Database links Help

Enzyme: EC:1.7.1.7

CluSTr: ALLvsALL:16299:65.9

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005993

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A0KN65 GMP reductase

O16294 Probable GMP reductase

P36959 GMP reductase 1

Q32L93 GMP reductase 2

Q99L27 GMP reductase 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013785	Aldolase-type TIM barrel
IPR005993	Guanosine monophosphate reductase 1
IPR015875	IMP dehydrogenase / GMP reductase, conserved site
IPR001093	IMP dehydrogenase/GMP reductase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

InterPro 23.1