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InterPro: IPR005962 Tyrosine 3-monooxygenase

Protein matches Help

UniProtKB

Matches:

44 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005962 Tyr_3_mOase

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01269	Tyr_3_monoox	44
Signatures in BioMart

InterPro Relationships Help

Parent

IPR019773 Tyrosine 3-monooxygenase-like

Contains

IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
IPR019774 Aromatic amino acid hydroxylase, C-terminal

GO Term annotation Help

Process

GO:0042423 catecholamine biosynthetic process
GO:0055114 oxidation reduction

Function

GO:0004511 tyrosine 3-monooxygenase activity

InterPro annotation

Entry Details in BioMart

Abstract

Tyrosine 3-monooxygenase (EC:1.14.16.2), is a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tryptophan 5-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. It catalyses the first step in catecholamine biosynthesis.

L-tyrosine + tetrahydropteridine + O2 = 3,4-dihydroxy-L-phenylalanine + dihydropteridine + H2O.

Structural links Help

PDB - click here

SCOP: d.178.1.1

CATH: 1.10.800.10

Database links Help

Enzyme: EC:1.14.16.2

PRIAM: PRI003744

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005962

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O17446 Tyrosine 3-monooxygenase

P04177 Tyrosine 3-monooxygenase

P07101 Tyrosine 3-monooxygenase

P18459 Tyrosine 3-monooxygenase

P24529 Tyrosine 3-monooxygenase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019773	Tyrosine 3-monooxygenase-like
IPR019774	Aromatic amino acid hydroxylase, C-terminal
IPR005962	Tyrosine 3-monooxygenase
IPR001273	Aromatic amino acid hydroxylase
IPR018301	Aromatic amino acid hydroxylase, iron/copper binding site
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Goodwill KE, Sabatier C, Marks C, Raag R, Fitzpatrick PF, Stevens RC. Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases. Nat. Struct. Biol. 4 1997 578-85 [PubMed: 9228951] http://dx.doi.org/10.1038/nsb0797-578
	Goodwill KE, Sabatier C, Stevens RC. Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site. Biochemistry 37 1998 13437-45 [PubMed: 9753429] http://dx.doi.org/10.1021/bi981462g

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