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InterPro: IPR005956 4-hydroxyphenylpyruvate dioxygenase

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UniProtKB

Matches:

779 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005956 4OHPhenylPyrv_dOase

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF009283	HPP_dOase	653
PANTHER	PTHR11959	HPP_dOase	769
TIGRFAMs	TIGR01263	4HPPD	632
Signatures in BioMart

InterPro Relationships Help

Contains

IPR004360 Glyoxalase/bleomycin resistance protein/dioxygenase

GO Term annotation Help

Process

GO:0009072 aromatic amino acid family metabolic process

Function

GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity

InterPro annotation

Entry Details in BioMart

Abstract

4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27) oxidises 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerisation into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is haemolytic [1]. In some bacterial species, this enzyme has been studied as a haemolysin.

Structural links Help

PDB - click here

SCOP: d.32.1.3

CATH: 3.10.180.10

Database links Help

CluSTr: ALLvsALL:3397:40.5

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005956

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P32754 4-hydroxyphenylpyruvate dioxygenase

P49429 4-hydroxyphenylpyruvate dioxygenase

P93836 4-hydroxyphenylpyruvate dioxygenase

Q18347 Putative protein C31H2.4

Q55810 Uncharacterized protein slr0090

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR004360	Glyoxalase/bleomycin resistance protein/dioxygenase
IPR005956	4-hydroxyphenylpyruvate dioxygenase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Hegedus ZL, Nayak U. Homogentisic acid and structurally related compounds as intermediates in plasma soluble melanin formation and in tissue toxicities. 102 175-81 1994 [PubMed: 8000039]

Additional Reading Open in usermanual
	Brownlee JM, Johnson-Winters K, Harrison DH, Moran GR. Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC. Biochemistry 43 2004 6370-7 [PubMed: 15157070] http://dx.doi.org/10.1021/bi049317s
	Fritze IM, Linden L, Freigang J, Auerbach G, Huber R, Steinbacher S. The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase. Plant Physiol. 134 2004 1388-400 [PubMed: 15084729] http://dx.doi.org/10.1104/pp.103.034082
	Yang C, Pflugrath JW, Camper DL, Foster ML, Pernich DJ, Walsh TA. Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases. Biochemistry 43 2004 10414-23 [PubMed: 15301540] http://dx.doi.org/10.1021/bi049323o
	Serre L, Sailland A, Sy D, Boudec P, Rolland A, Pebay-Peyroula E, Cohen-Addad C. Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway. Structure 7 1999 977-88 [PubMed: 10467142] http://dx.doi.org/10.1016/S0969-2126(99)80124-5

InterPro 23.1