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InterPro: IPR005931 Delta-1-pyrroline-5-carboxylate dehydrogenase 1

Protein matches Help

UniProtKB

Matches:

259 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005931 d-1-pyrroline-5-COlate_DH-1

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01236	D1pyr5carbox1	259
Signatures in BioMart

InterPro Relationships Help

Contains

IPR015590 Aldehyde dehydrogenase
IPR016162 Aldehyde dehydrogenase, N-terminal

GO Term annotation Help

Process

GO:0006561 proline biosynthetic process
GO:0055114 oxidation reduction

Function

GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity

Component

GO:0005759 mitochondrial matrix

InterPro annotation

Entry Details in BioMart

Abstract

The delta(1)-pyrroline-5-carboxylate synthetase (EC:1.5.1.12) a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine. It is the rate-limiting enzyme in proline biosynthesis and is subject to feedback inhibition by proline.

1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH

This model represents one of several related branches of delta-1-pyrroline-5-carboxylate dehydrogenase.

Database links Help

Enzyme: EC:1.5.1.12

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005931

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A7YWE4 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

O74766 Probable delta-1-pyrroline-5-carboxylate dehydrogenase

P07275 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

P30038 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

Q8CHT0 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR015590	Aldehyde dehydrogenase
IPR005931	Delta-1-pyrroline-5-carboxylate dehydrogenase 1
IPR016162	Aldehyde dehydrogenase, N-terminal
IPR016161	Aldehyde/histidinol dehydrogenase
IPR016160	Aldehyde dehydrogenase, conserved site
	SWISS-MODEL
	ModBase

Publications Help

InterPro 23.1