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InterPro: IPR005925 Putative agmatinase

Protein matches Help

UniProtKB

Matches:

1001 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005925 Agmatinase

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01230	agmatinase	1001
Signatures in BioMart

InterPro Relationships Help

Parent

IPR006035 Ureohydrolase

Contains

IPR020855 Ureohydrolase, manganese-binding site

GO Term annotation Help

Process

GO:0006596 polyamine biosynthetic process

Function

GO:0008783 agmatinase activity

InterPro annotation

Entry Details in BioMart

Abstract

Members of this family include known and predicted examples of agmatinase (agmatine ureohydrolase, EC:3.5.3.11) and members of archaea, for which no definitive agmatinase sequence has yet been made available. However, archaeal sequences are phylogenetically close to the experimentally verified Bacillus subtilis sequence. One species of Halobacterium has been demonstrated in vitro to produce agmatine from arginine, but no putrescine from ornithine, suggesting that arginine decarboxylase and agmatinase, rather than arginase and ornithine decarboxylase, lead from arginine to polyamine biosynthesis.

Structural links Help

PDB - click here

SCOP: c.42.1.1

CATH: 3.40.800.10

Database links Help

Enzyme: EC:3.5.3.11

CluSTr: ALLvsALL:42042:40.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005925

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A2AS89 Agmatinase, mitochondrial

P37819 Proclavaminate amidinohydrolase

P72703 Agmatinase 1

Q0D2L3 Agmatinase, mitochondrial

Q9BSE5 Agmatinase, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006035	Ureohydrolase
IPR020855	Ureohydrolase, manganese-binding site
IPR005924	Arginase
IPR005925	Putative agmatinase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Elkins JM, Clifton IJ, Hernandez H, Doan LX, Robinson CV, Schofield CJ, Hewitson KS. Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis. Biochem. J. 366 2002 423-34 [PubMed: 12020346] http://dx.doi.org/10.1042/BJ20020125
	Sekowska A, Danchin A, Risler JL. Phylogeny of related functions: the case of polyamine biosynthetic enzymes. Microbiology (Reading, Engl.) 146 ( Pt 8) 2000 1815-28 [PubMed: 10931887]

InterPro 23.1