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InterPro: IPR005914 Acetoacetyl-CoA synthase

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UniProtKB

Matches:

386 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005914 Acac_CoA_synth

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01217	ac_ac_CoA_syn	386
Signatures in BioMart

InterPro Relationships Help

Contains

IPR000873 AMP-dependent synthetase/ligase
IPR020845 AMP-binding, conserved site

GO Term annotation Help

Process

GO:0006629 lipid metabolic process

Function

GO:0030729 acetoacetate-CoA ligase activity

InterPro annotation

Entry Details in BioMart

Abstract

Isoprenoids are a large class of compounds, with more than 20,000 structures currently known, which are found in all living organisms. Some play essential physiological roles, such as sterols that stabilise cell membranes or carotenoids involved in photosynthesis, while the function of many others is not well understood. In all eukaryotes and some prokaryotes, isoprenoids are synthesised by the mevalonate pathway, while most prokaryotes use a mevalonate-independent pathway [1, 2].

This entry represents acetoacetyl-CoA synthase (EC:6.2.1.16), catalysing the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate.

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA

A Sinorhizobium protein in this entry is also required for growth on polyhydroxybutyrate, a commonly used carbon storage molecule in bacteria [3].

Database links Help

Enzyme: EC:6.2.1.16

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005914

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A3QK15 Acetoacetyl-CoA synthetase

Q21166 Acetoacetyl-CoA synthetase

Q86V21 Acetoacetyl-CoA synthetase

Q9D2R0 Acetoacetyl-CoA synthetase

Q9Z3R3 Acetoacetyl-coenzyme A synthetase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR020845	AMP-binding, conserved site
IPR005914	Acetoacetyl-CoA synthase
IPR000873	AMP-dependent synthetase/ligase
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Tabata K, Hashimoto S. Production of mevalonate by a metabolically-engineered Escherichia coli. Biotechnol. Lett. 26 1487-91 2004 [PubMed: 15604784] http://dx.doi.org/10.1023/B:BILE.0000044449.08268.7d
2.	Rohmer M, Knani M, Simonin P, Sutter B, Sahm H. Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. Biochem. J. 295 ( Pt 2) 517-24 1993 [PubMed: 8240251] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=8240251
3.	Cai GQ, Driscoll BT, Charles TC. Requirement for the enzymes acetoacetyl coenzyme A synthetase and poly-3-hydroxybutyrate (PHB) synthase for growth of Sinorhizobium meliloti on PHB cycle intermediates. J. Bacteriol. 182 2113-8 2000 [PubMed: 10735852] http://dx.doi.org/10.1128/JB.182.8.2113-2118.2000

InterPro 24.0