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InterPro: IPR005900 6-phosphogluconolactonase

Protein matches Help

UniProtKB

Matches:

993 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005900 6-phosphogluconolactonase

Type

Domain

Signatures Help

Database	ID	Name	Proteins
PANTHER	PTHR11054	Phosphogluconlac	964
TIGRFAMs	TIGR01198	pgl	929
Signatures in BioMart

InterPro Relationships Help

Contains

IPR006148 Glucosamine/galactosamine-6-phosphate isomerase

GO Term annotation Help

Process

GO:0006098 pentose-phosphate shunt

Function

GO:0017057 6-phosphogluconolactonase activity

InterPro annotation

Entry Details in BioMart

Abstract

6-phosphogluconolactonase (EC:3.1.1.31) is the enzyme responsible for the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, the second step in the pentose phosphate pathway.

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Structural links Help

PDB - click here

SCOP: c.124.1.1

CATH: 3.40.50.1360

Database links Help

Enzyme: EC:3.1.1.31

Taxonomic coverage Help

Example proteins Help

A6ZT71 6-phosphogluconolactonase 3

O18229 Putative 6-phosphogluconolactonase

O95336 6-phosphogluconolactonase

Q8CFX1 GDH/6PGL endoplasmic bifunctional protein

Q9VZ64 Probable 6-phosphogluconolactonase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016040	NAD(P)-binding domain
IPR001282	Glucose-6-phosphate dehydrogenase
IPR019796	Glucose-6-phosphate dehydrogenase, active site
IPR006148	Glucosamine/galactosamine-6-phosphate isomerase
IPR005900	6-phosphogluconolactonase
	SWISS-MODEL
	ModBase

Publications Help

Additional Reading Open in usermanual
	Collard F, Collet JF, Gerin I, Veiga-da-Cunha M, Van Schaftingen E. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1). FEBS Lett. 459 1999 223-6 [PubMed: 10518023] http://dx.doi.org/10.1016/S0014-5793(99)01247-8
	Hager PW, Calfee MW, Phibbs PV. The Pseudomonas aeruginosa devB/SOL homolog, pgl, is a member of the hex regulon and encodes 6-phosphogluconolactonase. J. Bacteriol. 182 2000 3934-41 [PubMed: 10869070] http://dx.doi.org/10.1128/JB.182.14.3934-3941.2000

InterPro 23.1