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InterPro: IPR005877 YSIRK Gram-positive signal peptide

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1990 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Architectures
Accession List
Matches in BioMart

Accession

IPR005877 Gpos_YSIRK

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04650	YSIRK_signal	1803
TIGRFAMs	TIGR01168	YSIRK_signal	1941
Signatures in BioMart

InterPro Relationships Help

Found in

IPR019929 Haem uptake protein IsdB
IPR019930 Haptoglobin-binding haem uptake protein HarA

GO Term annotation Help

Component

GO:0016020 membrane

InterPro annotation

Entry Details in BioMart

Abstract

Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology.

Structural links Help

PDB - click here

SCOP: a.8.1.1

CATH: 1.20.5.420

Database links Help

PANDIT: PF04650

Blocks: IPB005877

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005877

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P02976 Immunoglobulin G-binding protein A

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR009063	Immunoglobulin/albumin-binding
IPR019931	LPXTG-motif cell wall anchor
IPR005038	Octapeptide repeat
IPR002482	Peptidoglycan-binding Lysin subgroup
IPR018392	Peptidoglycan-binding lysin domain
IPR003132	Protein A, Ig-binding
IPR005877	YSIRK Gram-positive signal peptide
IPR001899	Surface protein from Gram-positive cocci
IPR019948	Gram-positive anchor
	PDB Chain
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Starovasnik MA, Skelton NJ, O'Connell MP, Kelley RF, Reilly D, Fairbrother WJ. Solution structure of the E-domain of staphylococcal protein A. Biochemistry 35 1996 15558-69 [PubMed: 8952510] http://dx.doi.org/10.1021/bi961409x
	Tashiro M, Tejero R, Zimmerman DE, Celda B, Nilsson B, Montelione GT. High-resolution solution NMR structure of the Z domain of staphylococcal protein A. J. Mol. Biol. 272 1997 573-90 [PubMed: 9325113] http://dx.doi.org/10.1006/jmbi.1997.1265
	Hogbom M, Eklund M, Nygren PA, Nordlund P. Structural basis for recognition by an in vitro evolved affibody. Proc. Natl. Acad. Sci. U.S.A. 100 2003 3191-6 [PubMed: 12604795] http://dx.doi.org/10.1073/pnas.0436100100
	Sato S, Religa TL, Daggett V, Fersht AR. Testing protein-folding simulations by experiment: B domain of protein A. Proc. Natl. Acad. Sci. U.S.A. 101 2004 6952-6 [PubMed: 15069202] http://dx.doi.org/10.1073/pnas.0401396101
	Bae T, Schneewind O. The YSIRK-G/S motif of staphylococcal protein A and its role in efficiency of signal peptide processing. J. Bacteriol. 185 2003 2910-9 [PubMed: 12700270] http://dx.doi.org/10.1128/JB.185.9.2910-2919.2003
	Zheng D, Aramini JM, Montelione GT. Validation of helical tilt angles in the solution NMR structure of the Z domain of Staphylococcal protein A by combined analysis of residual dipolar coupling and NOE data. Protein Sci. 13 2004 549-54 [PubMed: 14718654] http://dx.doi.org/10.1110/ps.03351704
	Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM. Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science 293 2001 498-506 [PubMed: 11463916] http://dx.doi.org/10.1126/science.1061217

InterPro 23.1