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InterPro: IPR005764 Adenine phosphoribosyl transferase

Protein matches Help

UniProtKB

Matches:

1601 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005764 Ade_phspho_trans

Type

Family

Signatures Help

Database	ID	Name	Proteins
HAMAP	MF_00004	Ade_phspho_trans	1386
TIGRFAMs	TIGR01090	apt	1457
Signatures in BioMart

InterPro Relationships Help

Parent

IPR000836 Phosphoribosyltransferase

Contains

IPR002375 Purine/pyrimidine phosphoribosyl transferase, conserved site

GO Term annotation Help

Process

GO:0006168 adenine salvage

Function

GO:0003999 adenine phosphoribosyltransferase activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

Adenine phosphoribosyltransferase (APRTase, EC:2.4.2.7) is a widely distributed enzyme, and its deficiency in humans causes the accumulation of 2,8-dihydroxyadenine. It is the sole catalyst for adenine recycling in most eukaryotes.

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate

Structural links Help

PDB - click here

SCOP: c.61.1.1

CATH: 3.40.50.2020

Database links Help

Enzyme: EC:2.4.2.7

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005764

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P07741 Adenine phosphoribosyltransferase

P08030 Adenine phosphoribosyltransferase

P12426 Adenine phosphoribosyltransferase

P49435 Adenine phosphoribosyltransferase 1

P91455 Adenine phosphoribosyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR005764	Adenine phosphoribosyl transferase
IPR000836	Phosphoribosyltransferase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Silva M, Silva CH, Iulek J, Thiemann OH. Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis. Biochemistry 43 2004 7663-71 [PubMed: 15196008] http://dx.doi.org/10.1021/bi0360758
	Shi W, Tanaka KS, Crother TR, Taylor MW, Almo SC, Schramm VL. Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry 40 2001 10800-9 [PubMed: 11535055] http://dx.doi.org/10.1021/bi010465h
	Silva CH, Silva M, Iulek J, Thiemann OH. Structural complexes of human adenine phosphoribosyltransferase reveal novel features of the APRT catalytic mechanism. J. Biomol. Struct. Dyn. 25 2008 589-97 [PubMed: 18399692]

InterPro 23.1