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InterPro: IPR005656 MmgE/PrpD

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UniProtKB

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1004 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Architectures
Accession List
Matches in BioMart

Accession

IPR005656 MmgE_PrpD

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03972	MmgE_PrpD	996
PANTHER	PTHR16943	MmgE_PrpD	655
SuperFamily	SSF103378	MmgE_PrpD	998
Signatures in BioMart

InterPro Relationships Help

Children

IPR012705 2-methylcitrate dehydratase PrpD

GO Term annotation Help

Process

GO:0019543 propionate catabolic process

Function

GO:0047547 2-methylcitrate dehydratase activity

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents proteins from the MmgE/PrpD family, which includes 2-methylcitrate dehydratase (PrpD; EC:4.2.1.79). PrpD is required for propionate catabolism, catalysing the third step of the 2-methylcitric acid cycle [1]. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha+beta domain [2].

Structural links Help

PDB - click here

SCOP: e.44.1.1

Database links Help

PANDIT: PF03972

Blocks: IPB005656

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005656

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A6NK06 Immune-responsive gene 1 protein homolog

P54987 Immune-responsive gene 1 protein

P77243 2-methylcitrate dehydratase

Q12428 Probable 2-methylcitrate dehydratase

Q54IJ0 Probable 2-methylcitrate dehydratase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR012705	2-methylcitrate dehydratase PrpD
IPR005656	MmgE/PrpD
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Lohkamp B, Bauerle B, Rieger PG, Schneider G. Three-dimensional structure of iminodisuccinate epimerase defines the fold of the MmgE/PrpD protein family. J. Mol. Biol. 362 2006 555-66 [PubMed: 16934291] http://dx.doi.org/10.1016/j.jmb.2006.07.051
	Blank L, Green J, Guest JR. AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates. Microbiology (Reading, Engl.) 148 2002 133-46 [PubMed: 11782506] http://mic.sgmjournals.org/cgi/content/abstract/148/1/133
	Horswill AR, Escalante-Semerena JC. In vitro conversion of propionate to pyruvate by Salmonella enterica enzymes: 2-methylcitrate dehydratase (PrpD) and aconitase Enzymes catalyze the conversion of 2-methylcitrate to 2-methylisocitrate. Biochemistry 40 2001 4703-13 [PubMed: 11294638] http://dx.doi.org/10.1021/bi015503b

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