EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR005599 Alg9-like mannosyltransferase

Protein matches Help

UniProtKB

Matches:

523 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005599 Alg9_trans

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03901	Glyco_transf_22	514
PANTHER	PTHR22760	Alg9_trans	493
Signatures in BioMart

GO Term annotation Help

Process

GO:0006506 GPI anchor biosynthetic process

Function

GO:0016757 transferase activity, transferring glycosyl groups

Component

GO:0031227 intrinsic to endoplasmic reticulum membrane

InterPro annotation

Entry Details in BioMart

Abstract

Members of this family are mannosyltransferase enzymes [1, 2]. At least some members are localised in endoplasmic reticulum and involved in GPI anchor biosynthesis [3, 4]. In yeast the SMP3 (YOR149C) has been implemented in plasmid stability [5].

Database links Help

Enzyme: EC:2.4.1

PANDIT: PF03901

Blocks: IPB005599

Pfam Clan: CL0111.7

Taxonomic coverage Help

Example proteins Help

P30777 GPI mannosyltransferase 3

P54002 Putative glycosyltransferase C14A4.3

Q86VD9 GPI mannosyltransferase 4

Q8BTP0 GPI mannosyltransferase 4

Q8MT80 GPI mannosyltransferase 4

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR005599	Alg9-like mannosyltransferase
	ModBase

Publications Open in usermanual
1.	Sutterlin C, Escribano MV, Gerold P, Maeda Y, Mazon MJ, Kinoshita T, Schwarz RT, Riezman H. Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis. Biochem. J. 332 ( Pt 1) 153-9 1998 [PubMed: 9576863] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=9576863
2.	Nagamune K, Nozaki T, Maeda Y, Ohishi K, Fukuma T, Hara T, Schwarz RT, Sutterlin C, Brun R, Riezman H, Kinoshita T. Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei. Proc. Natl. Acad. Sci. U.S.A. 97 10336-41 2000 [PubMed: 10954751] http://dx.doi.org/10.1073/pnas.180230697
3.	Oriol R, Martinez-Duncker I, Chantret I, Mollicone R, Codogno P. Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. Mol. Biol. Evol. 19 1451-63 2002 [PubMed: 12200473] http://mbe.oxfordjournals.org/cgi/content/abstract/19/9/1451.pdf
4.	Baysal BE, Willett-Brozick JE, Badner JA, Corona W, Ferrell RE, Nimgaonkar VL, Detera-Wadleigh SD. A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family. Neurogenetics 4 43-53 2002 [PubMed: 12030331] http://dx.doi.org/10.1007/s10048-001-0129-x
5.	Irie K, Araki H, Oshima Y. Mutations in a Saccharomyces cerevisiae host showing increased holding stability of the heterologous plasmid pSR1. Mol. Gen. Genet. 225 257-65 1991 [PubMed: 2005867] http://dx.doi.org/10.1007/BF00269857

InterPro 23.1