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InterPro: IPR005257 Anthranilate synthase component I, TrpE

Protein matches Help

UniProtKB

Matches:

326 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR005257 TrpE_synth

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00565	trpE_proteo	326
Signatures in BioMart

InterPro Relationships Help

Contains

IPR005801 ADC synthase
IPR006805 Anthranilate synthase component I, N-terminal
IPR015890 Chorismate binding, C-terminal
IPR019999 Anthranilate synthase component I, C-terminal

GO Term annotation Help

Process

GO:0009058 biosynthetic process

Function

GO:0004049 anthranilate synthase activity

InterPro annotation

Entry Details in BioMart

Abstract

This family represents anthranilate/para-aminobenzoate synthase component I from proteobacteria and actinobacteria.

This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. This group includes proteobacteria such as Escherichia coli and Helicobacter pylori (Campylobacter pylori) but also the Gram-positive organism Corynebacterium glutamicum. The second group (IPR005256) includes eukaryotes, archaea, and most other bacterial lineages; sequences from the second group may resemble pabB more closely than other trpE from this group.

Structural links Help

PDB - click here

SCOP: d.161.1.1

CATH: 3.60.120.10

Database links Help

Enzyme: EC:4.1.3.27

CluSTr: ALLvsALL:57665:110.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005257

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P00897 Anthranilate synthase component 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019999	Anthranilate synthase component I, C-terminal
IPR006805	Anthranilate synthase component I, N-terminal
IPR005801	ADC synthase
IPR015890	Chorismate binding, C-terminal
IPR005257	Anthranilate synthase component I, TrpE
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Morollo AA, Eck MJ. Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium. Nat. Struct. Biol. 8 2001 243-7 [PubMed: 11224570] http://dx.doi.org/10.1038/84988
	Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE. The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Proc. Natl. Acad. Sci. U.S.A. 98 2001 6021-6 [PubMed: 11371633] http://dx.doi.org/10.1073/pnas.111150298

InterPro 23.1