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InterPro: IPR005144 ATP-cone

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3433 proteins

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Accession

IPR005144 ATP-cone

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03477	ATP-cone	3280
PROSITE profile	PS51161	ATP_CONE	3428
Signatures in BioMart

InterPro Relationships Help

Found in

IPR003796 Ribonucleotide reductase regulator NrdR-like
IPR008926 Ribonucleotide reductase R1 subunit, N-terminal
IPR020872 2-phosphoglycerate kinase

InterPro annotation

Entry Details in BioMart

Abstract

The ATP-cone is an evolutionarily mobile, ATP-binding regulatory domain which is found in a variety of proteins including ribonucleotide reductases, phosphoglycerate kinases and transcriptional regulators [1].

In ribonucleotide reductase protein R1 (P28903) from Escherichia coli this domain is located at the N terminus, and is composed mostly of helices [2]. It forms part of the allosteric effector region and contains the general allosteric activity site in a cleft located at the tip of the N-terminal region [3]. This site binds either ATP (activating) or dATP (inhibitory), with the base bound in a hydrophobic pocket and the phosphates bound to basic residues. Substrate binding to this site is thought to affect enzyme activity by altering the relative positions of the two subunits of ribonucleotide reductase.

Structural links Help

PDB - click here

SCOP: a.98.1.1

Database links Help

PROSITE doc: PDOC51161

PANDIT: PF03477

Blocks: IPB005144

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005144

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P07742 Ribonucleoside-diphosphate reductase large subunit

P21524 Ribonucleoside-diphosphate reductase large chain 1

P23921 Ribonucleoside-diphosphate reductase large subunit

P48591 Ribonucleoside-diphosphate reductase large subunit

Q03604 Ribonucleoside-diphosphate reductase large subunit

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000788	Ribonucleotide reductase large subunit, C-terminal
IPR008926	Ribonucleotide reductase R1 subunit, N-terminal
IPR013509	Ribonucleotide reductase large subunit, N-terminal
IPR005144	ATP-cone
IPR013346	Ribonucleoside-diphosphate reductase, alpha subunit
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Aravind L, Wolf YI, Koonin EV. The ATP-cone: an evolutionarily mobile, ATP-binding regulatory domain. J. Mol. Microbiol. Biotechnol. 2 191-4 2000 [PubMed: 10939243]
2.	Uhlin U, Eklund H. Structure of ribonucleotide reductase protein R1. Nature 370 533-9 1994 [PubMed: 8052308] http://dx.doi.org/10.1038/370533a0
3.	Eriksson M, Uhlin U, Ramaswamy S, Ekberg M, Regnstrom K, Sjoberg BM, Eklund H. Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure 5 1077-92 1997 [PubMed: 9309223] http://dx.doi.org/10.1016/S0969-2126(97)00259-1

Additional Reading Open in usermanual
	Persson AL, Eriksson M, Katterle B, Potsch S, Sahlin M, Sjoberg BM. A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J. Biol. Chem. 272 1997 31533-41 [PubMed: 9395490] http://dx.doi.org/10.1074/jbc.272.50.31533

InterPro 23.1