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InterPro: IPR005135 Endonuclease/exonuclease/phosphatase

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9873 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR005135 Endo/exonuclease/phosphatase

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03372	Exo_endo_phos	8989
SuperFamily	SSF56219	Exo_endo_phos	9781
Signatures in BioMart

InterPro Relationships Help

Children

IPR000300 Inositol polyphosphate related phosphatase
IPR004808 Exodeoxyribonuclease III xth

Found in

IPR003539 Cytolethal distending toxin B
IPR008185 Deoxyribonuclease I, eukaryotic
IPR016202 Deoxyribonuclease I-like
IPR017766 Sphingomyelinase C/phospholipase C

Contains

IPR018057 Deoxyribonuclease I, active site
IPR020847 AP endonuclease, family 1, binding site
IPR020848 AP endonuclease, family 1, conserved site

InterPro annotation

Entry Details in BioMart

Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [1]. Proteins this domain is found in include: AP endonuclease proteins (EC:4.2.99.18), DNase I proteins (EC:3.1.21.1), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC:3.1.3.56) and Sphingomyelinase (EC:3.1.4.12).

Structural links Help

PDB - click here

SCOP: d.151.1.1 , d.151.1.2 , d.151.1.3

CATH: 3.60.10.10

Database links Help

PANDIT: PF03372

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR005135

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O15056 Synaptojanin-2

O35710 Nocturnin

O45870 Putative neutral sphingomyelinase

P16425 Putative 115 kDa protein in type-1 retrotransposable element R1DM

P25618 Protein CWH43

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019402	Frag1/DRAM/Sfk1
IPR015047	Domain of unknown function DUF1866
IPR000504	RNA recognition motif, RNP-1
IPR000477	RNA-directed DNA polymerase (reverse transcriptase)
IPR005135	Endonuclease/exonuclease/phosphatase
IPR015706	RNA-directed DNA polymerase (reverse transcriptase), related
IPR002013	Synaptojanin, N-terminal
IPR000300	Inositol polyphosphate related phosphatase
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Dlakic M. Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Trends Biochem. Sci. 25 272-3 2000 [PubMed: 10838565] http://dx.doi.org/10.1016/S0968-0004(00)01582-6

Additional Reading Open in usermanual
	Lahm A, Suck D. DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. J. Mol. Biol. 222 1991 645-67 [PubMed: 1748997] http://dx.doi.org/10.1016/0022-2836(91)90502-W
	Kudryashov DS, Durer ZA, Ytterberg AJ, Sawaya MR, Pashkov I, Prochazkova K, Yeates TO, Loo RR, Loo JA, Satchell KJ, Reisler E. Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin. Proc. Natl. Acad. Sci. U.S.A. 105 2008 18537-42 [PubMed: 19015515] http://dx.doi.org/10.1073/pnas.0808082105
	Carpenter EP, Corbett A, Thomson H, Adacha J, Jensen K, Bergeron J, Kasampalidis I, Exley R, Winterbotham M, Tang C, Baldwin GS, Freemont P. AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis. EMBO J. 26 2007 1363-72 [PubMed: 17318183] http://dx.doi.org/10.1038/sj.emboj.7601593
	Repanas K, Zingler N, Layer LE, Schumann GG, Perrakis A, Weichenrieder O. Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease. Nucleic Acids Res. 35 2007 4914-26 [PubMed: 17626046] http://dx.doi.org/10.1093/nar/gkm516
	Lee SH, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R. Structural basis for the actin-binding function of missing-in-metastasis. Structure 15 2007 145-55 [PubMed: 17292833] http://dx.doi.org/10.1016/j.str.2006.12.005
	Georgiadis MM, Luo M, Gaur RK, Delaplane S, Li X, Kelley MR. Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease. Mutat. Res. 643 2008 54-63 [PubMed: 18579163] http://dx.doi.org/10.1016/j.mrfmmm.2008.04.008
	Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Nature 374 1995 381-6 [PubMed: 7885481] http://dx.doi.org/10.1038/374381a0

InterPro 23.1