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InterPro: IPR004981 Tryptophan 2,3-dioxygenase

Protein matches Help

UniProtKB

Matches:

427 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004981 Trp_2_3_dOase

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03301	Trp_dioxygenase	412
PANTHER	PTHR10138	Trp_2_3_dOase	422
Signatures in BioMart

InterPro Relationships Help

Children

IPR017485 Tryptophan 2,3-dioxygenase, bacteria

GO Term annotation Help

Process

GO:0019441 tryptophan catabolic process to kynurenine
GO:0055114 oxidation reduction

Function

GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity

InterPro annotation

Entry Details in BioMart

Abstract

This is a family of tryptophan 2,3-dioxygenase (EC:1.13.11.11) enzymes involved in tryptophan metabolism, which catalyse the reaction:

L-Tryptophan + O(2) = L-Formylkynurenine

Structural links Help

PDB - click here

SCOP: a.266.1.1

Database links Help

Enzyme: EC:1.13.11.11

PANDIT: PF03301

Blocks: IPB004981

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004981

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P20351 Tryptophan 2,3-dioxygenase

P48775 Tryptophan 2,3-dioxygenase

P48776 Tryptophan 2,3-dioxygenase

Q09474 Tryptophan 2,3-dioxygenase

Q1LK00 Tryptophan 2,3-dioxygenase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017485	Tryptophan 2,3-dioxygenase, bacteria
IPR004981	Tryptophan 2,3-dioxygenase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

Additional Reading Open in usermanual
	Forouhar F, Anderson JL, Mowat CG, Vorobiev SM, Hussain A, Abashidze M, Bruckmann C, Thackray SJ, Seetharaman J, Tucker T, Xiao R, Ma LC, Zhao L, Acton TB, Montelione GT, Chapman SK, Tong L. Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase. Proc. Natl. Acad. Sci. U.S.A. 104 2007 473-8 [PubMed: 17197414] http://dx.doi.org/10.1073/pnas.0610007104
	Comings DE, Muhleman D, Dietz G, Sherman M, Forest GL. Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat. Genomics 29 1995 390-6 [PubMed: 8666386] http://dx.doi.org/10.1006/geno.1995.9990

InterPro 23.1