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InterPro: IPR004867 Glycoside hydrolase, family 20, C-terminal

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Matches:

145 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession

IPR004867 Glyco_hydro_20_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03174	CHB_HEX_C	145
Signatures in BioMart

InterPro Relationships Help

Parent

IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain

Found in

IPR014756 Immunoglobulin E-set

GO Term annotation Help

Process

GO:0005975 carbohydrate metabolic process

Function

GO:0004563 beta-N-acetylhexosaminidase activity

InterPro annotation

Entry Details in BioMart

Abstract

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

This short domain is found in members of the glycoside hydrolase family 20 (GH20) and represents the C-terminal domain in chitobiases and beta-hexosaminidases EC:3.2.1.52. It is composed of a beta sandwich structure [5]. The function of this domain is unknown.

Structural links Help

PDB - click here

SCOP: b.1.18.2

CATH: 2.60.40.320 , 3.20.20.80

Database links Help

Enzyme: EC:3.2.1.52

CAZy: GH20

PANDIT: PF03174

Blocks: IPB004867

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004867

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

Q54468 Chitobiase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR013812	Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain
IPR012291	Cellulose-binding family II/chitobiase, carbohydrate-binding domain
IPR004867	Glycoside hydrolase, family 20, C-terminal
IPR014756	Immunoglobulin E-set
IPR015883	Glycoside hydrolase, family 20, catalytic core
IPR008965	Carbohydrate-binding
IPR015882	Beta-N-acetylhexosaminidase-like
IPR004866	Carbohydrate-binding, chitobiase/hexosaminidase-type, N-terminal
IPR017853	Glycoside hydrolase, catalytic core
IPR001540	Glycoside hydrolase, family 20
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc. Natl. Acad. Sci. U.S.A. 92 7090-4 1995 [PubMed: 7624375] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7624375&action=stream&blobtype=pdf
2.	Davies G, Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 3 853-9 1995 [PubMed: 8535779] http://dx.doi.org/10.1016/S0969-2126(01)00220-9
3.	Bairoch A. Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT. 1999
4.	Henrissat B, Coutinho PM. Carbohydrate-Active Enzymes server. 1999
5.	Tews I, Perrakis A, Oppenheim A, Dauter Z, Wilson KS, Vorgias CE. Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease. Nat. Struct. Biol. 3 638-48 1996 [PubMed: 8673609] http://dx.doi.org/10.1038/nsb0796-638

Additional Reading Open in usermanual
	Prag G, Papanikolau Y, Tavlas G, Vorgias CE, Petratos K, Oppenheim AB. Structures of chitobiase mutants complexed with the substrate Di-N-acetyl-d-glucosamine: the catalytic role of the conserved acidic pair, aspartate 539 and glutamate 540. J. Mol. Biol. 300 2000 611-7 [PubMed: 10884356] http://dx.doi.org/10.1006/jmbi.2000.3906

InterPro 23.1