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InterPro: IPR004827 Basic-leucine zipper (bZIP) transcription factor

Protein matches Help

UniProtKB

Matches:

4445 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004827 TF_bZIP

Secondary

IPR001871

Type

Domain

Signatures Help

Database	ID	Name	Proteins
PROSITE pattern	PS00036	BZIP_BASIC	2894
PROSITE profile	PS50217	BZIP	3497
SMART	SM00338	BRLZ	4233
Signatures in BioMart

InterPro Relationships Help

Children

IPR004826 Maf transcription factor
IPR011616 bZIP transcription factor, bZIP-1
IPR011700 Basic leucine zipper

Contains

IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding

GO Term annotation Help

Process

GO:0006355 regulation of transcription, DNA-dependent

Function

GO:0003700 transcription factor activity
GO:0043565 sequence-specific DNA binding

InterPro annotation

Entry Details in BioMart

Abstract

The basic-leucine zipper (bZIP) transcription factors [1, 2] of eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region (see IPR002158) required for dimerization.

Structural links Help

PDB - click here

SCOP: a.37.1.1 , h.1.26.1 , h.1.3.1 , h.1.5.1 , h.3.2.1 , k.1.1.1 , k.31.1.1 , k.6.1.1

CATH: 1.10.287.210 , 1.10.880.10 , 1.20.5.170

Database links Help

PDBe-motif: PS00036

PROSITE doc: PDOC00036

Blocks: IPB004827

Interactions Help

This domain has been experimentally proven to be involved in Protein:Protein interactions.
Representative data is shown with the following example proteins:

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004827

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A8MPH9 Transcription factor kayak, isoforms D/sro

O14867 Transcription regulator protein BACH1

O54790 Transcription factor MafG

P03069 General control protein GCN4

P34707 Protein skinhead-1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013089	Kelch related
IPR013069	BTB/POZ
IPR011333	BTB/POZ fold
IPR000837	Fos transforming protein
IPR000210	BTB/POZ-like
IPR004827	Basic-leucine zipper (bZIP) transcription factor
IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
IPR004826	Maf transcription factor
IPR011616	bZIP transcription factor, bZIP-1
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Hurst HC. Transcription factors 1: bZIP proteins. 2 101-68 1995 [PubMed: 7780801]
2.	Ellenberger T. Getting a grip in DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains. Curr. Opin. Struct. Biol. 4 12-21 1994

Additional Reading Open in usermanual
	Deng Y, Liu J, Zheng Q, Li Q, Kallenbach NR, Lu M. A heterospecific leucine zipper tetramer. Chem. Biol. 15 2008 908-19 [PubMed: 18804028] http://dx.doi.org/10.1016/j.chembiol.2008.07.008
	Datta S, Johansson H, Hettiarachchi C, Irigoyen ML, Desai M, Rubio V, Holm M. LZF1/SALT TOLERANCE HOMOLOG3, an Arabidopsis B-box protein involved in light-dependent development and gene expression, undergoes COP1-mediated ubiquitination. Plant Cell 20 2008 2324-38 [PubMed: 18796637] http://dx.doi.org/10.1105/tpc.108.061747
	Kuras L, Cherest H, Surdin-Kerjan Y, Thomas D. A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism. EMBO J. 15 1996 2519-29 [PubMed: 8665859] http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=8665859&action=stream&blobtype=pdf
	Brown JH, Yang Y, Reshetnikova L, Gourinath S, Suveges D, Kardos J, Hobor F, Reutzel R, Nyitray L, Cohen C. An unstable head-rod junction may promote folding into the compact off-state conformation of regulated myosins. J. Mol. Biol. 375 2008 1434-43 [PubMed: 18155233] http://dx.doi.org/10.1016/j.jmb.2007.11.071
	Petosa C, Morand P, Baudin F, Moulin M, Artero JB, Muller CW. Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein. Mol. Cell 21 2006 565-72 [PubMed: 16483937] http://dx.doi.org/10.1016/j.molcel.2006.01.006
	Baranger AM. Accessory factor-bZIP-DNA interactions. 2 1998 18-23 [PubMed: 9667910] http://dx.doi.org/10.1016/S1367-5931(98)80031-8
	Liu J, Zheng Q, Deng Y, Cheng CS, Kallenbach NR, Lu M. A seven-helix coiled coil. Proc. Natl. Acad. Sci. U.S.A. 103 2006 15457-62 [PubMed: 17030805] http://dx.doi.org/10.1073/pnas.0604871103
	Ellenberger TE, Brandl CJ, Struhl K, Harrison SC. The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell 71 1992 1223-37 [PubMed: 1473154] http://dx.doi.org/10.1016/S0092-8674(05)80070-4
	Yadav MK, Leman LJ, Price DJ, Brooks CL 3rd, Stout CD, Ghadiri MR. Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution. Biochemistry 45 2006 4463-73 [PubMed: 16584182] http://dx.doi.org/10.1021/bi060092q

InterPro 23.1