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InterPro: IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase

Protein matches Help

UniProtKB

Matches:

1803 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004733 PurM_cligase

Type

Domain

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00878	purM	1803
Signatures in BioMart

InterPro Relationships Help

Contains

IPR000728 AIR synthase related protein
IPR010918 AIR synthase related protein, C-terminal

GO Term annotation Help

Process

GO:0006189 'de novo' IMP biosynthetic process

Function

GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

The purine biosynthetic pathway in procaryotes enlists eleven enzymes, six of which use ATP. Enzymes 5 and 6 of this pathway, formylglycinamide ribonucleotide (FGAR) amidotransferase (PurL) and aminoimidazole ribonucleotide (AIR) synthetase (PurM) utilise ATP to activate the oxygen of an amide within their substrate toward nucleophilic attack by a nitrogen. AIR synthetase uses the product of PurL, formylglycinamidine ribonucleotide (FGAM) and ATP to make AIR, ADP and P(i).

Structural links Help

PDB - click here

SCOP: d.139.1.1 , d.79.4.1

CATH: 3.30.1330.10 , 3.90.650.10

Database links Help

Enzyme: EC:6.3.3.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004733

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P00967 Trifunctional purine biosynthetic protein adenosine-3

P07244 Bifunctional purine biosynthetic protein ADE5,7

P22102 Trifunctional purine biosynthetic protein adenosine-3

Q05728 Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic

Q64737 Trifunctional purine biosynthetic protein adenosine-3

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013815	ATP-grasp fold, subdomain 1
IPR013816	ATP-grasp fold, subdomain 2
IPR002376	Formyl transferase, N-terminal
IPR013817	Pre-ATP-grasp fold
IPR020559	Phosphoribosylglycinamide synthetase, conserved site
IPR004607	Phosphoribosylglycinamide formyltransferase
IPR016188	PurM, N-terminal-like
IPR016185	PreATP-grasp-like fold
IPR011761	ATP-grasp fold
IPR001555	Phosphoribosylglycinamide formyltransferase, active site
IPR010918	AIR synthase related protein, C-terminal
IPR004733	Phosphoribosylformylglycinamidine cyclo-ligase
IPR011054	Rudiment single hybrid motif
IPR020561	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
IPR020560	Phosphoribosylglycinamide synthetase, C-domain
IPR020562	Phosphoribosylglycinamide synthetase, N-domain
IPR000728	AIR synthase related protein
IPR000115	Phosphoribosylglycinamide synthetase
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Li C, Kappock TJ, Stubbe J, Weaver TM, Ealick SE. X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution. Structure 7 1999 1155-66 [PubMed: 10508786] http://dx.doi.org/10.1016/S0969-2126(99)80182-8

InterPro 23.1