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InterPro: IPR004732 Transaldolase subfamily

Protein matches Help

UniProtKB

Matches:

313 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004732 Tal_mycobact

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00876	tal_mycobact	313
Signatures in BioMart

InterPro Relationships Help

Parent

IPR001585 Transaldolase

Children

IPR014634 Transaldolase, bacterial/plant type

Contains

IPR013785 Aldolase-type TIM barrel
IPR018225 Transaldolase, active site

GO Term annotation Help

Process

GO:0006098 pentose-phosphate shunt

Function

GO:0004801 transaldolase activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

Transaldolase (EC:2.2.1.2) catalyzes the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldolase is an enzyme of about 34 Kd whose sequence has been well conserved throughout evolution. A lysine has been implicated [1] in the catalytic mechanism of the enzyme; it acts as a nucleophilic group that attacks the carbonyl group of fructose-6-phosphate.

Transaldolase is evolutionary related [2] to a bacterial protein of about 20 Kd (known as talC in Escherichia coli), whose exact function is not yet known.

Database links Help

Enzyme: EC:2.2.1.2

CluSTr: ALLvsALL:32965:82.6

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004732

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P48983 Transaldolase 2

Q5F6E9 Transaldolase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR018225	Transaldolase, active site
IPR013785	Aldolase-type TIM barrel
IPR001585	Transaldolase
IPR004732	Transaldolase subfamily
IPR014634	Transaldolase, bacterial/plant type
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Miosga T, Schaaff-Gerstenschlager I, Franken E, Zimmermann FK. Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase. Yeast 9 1241-9 1993 [PubMed: 8109173] http://dx.doi.org/10.1002/yea.320091111
2.	Reizer J, Reizer A, Saier MH Jr. Novel phosphotransferase system genes revealed by bacterial genome analysis--a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system. Microbiology (Reading, Engl.) 141 ( Pt 4) 961-71 1995 [PubMed: 7773398]

InterPro 23.1