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InterPro: IPR004675 Alkylhydroperoxidase AhpD core

Protein matches Help

UniProtKB

Matches:

1944 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
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Accession

IPR004675 AhpD_core

Type

Domain

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00778	ahpD_dom	1944
Signatures in BioMart

InterPro Relationships Help

Found in

IPR004674 Alkylhydroperoxidase AhpD
IPR010195 Uncharacterised peroxidase-related

InterPro annotation

Entry Details in BioMart

Abstract

This group represents a 51-residue core region of homology among a family of mostly uncharacterised proteins of 110 to 227 amino acids. Most members of this family contain the motif Exxxxxx[SA]xxxxC[VIL]xCxxxH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterised peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. Peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity.

Structural links Help

PDB - click here

SCOP: a.152.1.1 , a.152.1.2 , a.152.1.3 , a.152.1.4

CATH: 1.20.1290.10

Database links Help

Enzyme: EC:1.11.1.15

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004675

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P0A5N4 Alkyl hydroperoxide reductase ahpD

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003779	Carboxymuconolactone decarboxylase
IPR004675	Alkylhydroperoxidase AhpD core
IPR004674	Alkylhydroperoxidase AhpD
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Bryk R, Lima CD, Erdjument-Bromage H, Tempst P, Nathan C. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 295 2002 1073-7 [PubMed: 11799204] http://dx.doi.org/10.1126/science.1067798
	Nunn CM, Djordjevic S, Hillas PJ, Nishida CR, Ortiz de Montellano PR. The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design. J. Biol. Chem. 277 2002 20033-40 [PubMed: 11914371] http://dx.doi.org/10.1074/jbc.M200864200
	Koshkin A, Nunn CM, Djordjevic S, Ortiz de Montellano PR. The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined by mutagenesis, crystallography, and kinetics. J. Biol. Chem. 278 2003 29502-8 [PubMed: 12761216] http://dx.doi.org/10.1074/jbc.M303747200

InterPro 23.1