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InterPro: IPR004674 Alkylhydroperoxidase AhpD

Protein matches Help

UniProtKB

Matches:

101 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004674 AhpD

Type

Family

Signatures Help

Database	ID	Name	Proteins
HAMAP	MF_01676	AhpD	80
TIGRFAMs	TIGR00777	ahpD	91
Signatures in BioMart

InterPro Relationships Help

Contains

IPR003779 Carboxymuconolactone decarboxylase
IPR004675 Alkylhydroperoxidase AhpD core

GO Term annotation Help

Process

GO:0055114 oxidation reduction

Function

GO:0004601 peroxidase activity

InterPro annotation

Entry Details in BioMart

Abstract

Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon.

Structural links Help

PDB - click here

SCOP: a.152.1.1

CATH: 1.20.1290.10

Database links Help

Enzyme: EC:1.11.1.15

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004674

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P0A5N4 Alkyl hydroperoxide reductase ahpD

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003779	Carboxymuconolactone decarboxylase
IPR004675	Alkylhydroperoxidase AhpD core
IPR004674	Alkylhydroperoxidase AhpD
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Bryk R, Lima CD, Erdjument-Bromage H, Tempst P, Nathan C. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 295 2002 1073-7 [PubMed: 11799204] http://dx.doi.org/10.1126/science.1067798
	Nunn CM, Djordjevic S, Hillas PJ, Nishida CR, Ortiz de Montellano PR. The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design. J. Biol. Chem. 277 2002 20033-40 [PubMed: 11914371] http://dx.doi.org/10.1074/jbc.M200864200
	Koshkin A, Nunn CM, Djordjevic S, Ortiz de Montellano PR. The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined by mutagenesis, crystallography, and kinetics. J. Biol. Chem. 278 2003 29502-8 [PubMed: 12761216] http://dx.doi.org/10.1074/jbc.M303747200

InterPro 23.1