A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including
argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase
(fumarase), and tartrate dehydratase (see IPR000362). Proteins in this group represent
a subset of closely related proteins or modules, including the Escherichia coli tartrate dehydratase
beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is
homologous to the tartrate dehydratase alpha chain). The activity of the archaeal proteins in
this group is unknown.
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