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InterPro: IPR004631 4-aminobutyrate aminotransferase, eukaryotic

Protein matches Help

UniProtKB

Matches:

149 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004631 4NH2But_aminotransferase_euk

Type

Family

Signatures Help

Database	ID	Name	Proteins
PANTHER	PTHR11986:SF6	GABAtrns_euk	148
TIGRFAMs	TIGR00699	GABAtrns_euk	114
Signatures in BioMart

InterPro Relationships Help

Parent

IPR005814 Aminotransferase class-III

Contains

IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
IPR015424 Pyridoxal phosphate-dependent transferase, major domain

GO Term annotation Help

Process

GO:0009448 gamma-aminobutyric acid metabolic process

Function

GO:0003867 4-aminobutyrate transaminase activity

InterPro annotation

Entry Details in BioMart

Abstract

4-aminobutyrate aminotransferase eukaryotic (EC:2.6.1.19) is a class III pyridoxal-phosphate-dependent aminotransferase. The enzyme catalyses the conversion of 4-aminobutanoate and 2-oxoglutarate into succinate semialdehyde and L-glutamate. The degree of sequence difference between this set and known bacterial examples is greater than the distance between either set the most similar enzyme with distinct function, and so the prokaryotic and eukaryotic sets have been placed into separate families. This family describes known eukaryotic examples of the enzyme. Alternate names include GABA transaminase, gamma-amino-N-butyrate transaminase, and beta-alanine--oxoglutarate aminotransferase.

Structural links Help

PDB - click here

SCOP: c.67.1.4

CATH: 3.40.640.10 , 3.90.1150.10

Database links Help

Enzyme: EC:2.6.1.19

PRIAM: PRI001251

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004631

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P17649 4-aminobutyrate aminotransferase

P61922 4-aminobutyrate aminotransferase, mitochondrial

P80147 4-aminobutyrate aminotransferase, mitochondrial

P80404 4-aminobutyrate aminotransferase, mitochondrial

Q21217 Probable 4-aminobutyrate aminotransferase, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR005814	Aminotransferase class-III
IPR004631	4-aminobutyrate aminotransferase, eukaryotic
IPR015424	Pyridoxal phosphate-dependent transferase, major domain
IPR015421	Pyridoxal phosphate-dependent transferase, major region, subdomain 1
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Storici P, De Biase D, Bossa F, Bruno S, Mozzarelli A, Peneff C, Silverman RB, Schirmer T. Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin. J. Biol. Chem. 279 2004 363-73 [PubMed: 14534310] http://dx.doi.org/10.1074/jbc.M305884200
	Storici P, Capitani G, De Biase D, Moser M, John RA, Jansonius JN, Schirmer T. Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy. Biochemistry 38 1999 8628-34 [PubMed: 10393538] http://dx.doi.org/10.1021/bi990478j

InterPro 24.0