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InterPro: IPR004628 Mannonate dehydratase

Protein matches Help

UniProtKB

Matches:

542 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004628 Man_deHydtase

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03786	UxuA	542
PIRSF	PIRSF016049	Man_dehyd	489
TIGRFAMs	TIGR00695	uxuA	485
Signatures in BioMart

InterPro Relationships Help

Contains

IPR013022 Xylose isomerase-like, TIM barrel domain

GO Term annotation Help

Process

GO:0006064 glucuronate catabolic process

Function

GO:0008927 mannonate dehydratase activity

InterPro annotation

Entry Details in BioMart

Abstract

This Fe2+-requiring enzyme plays a role in D-glucuronate catabolism in Escherichia coli. Mannonate dehydratase converts D-mannonate to 2-dehydro-3-deoxy-D-gluconate. An apparent equivalog is found in a glucuronate utilization operon in Bacillus stearothermophilus T-6.

Structural links Help

PDB - click here

SCOP: c.1.15.6

CATH: 3.20.20.150

Database links Help

Enzyme: EC:4.2.1.8

PANDIT: PF03786

Blocks: IPB004628

Pfam Clan: CL0152.8

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004628

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A4VVI4 Mannonate dehydratase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR004628	Mannonate dehydratase
IPR013022	Xylose isomerase-like, TIM barrel domain
	PDB Chain

Publications Help

Additional Reading Open in usermanual
	Shulami S, Gat O, Sonenshein AL, Shoham Y. The glucuronic acid utilization gene cluster from Bacillus stearothermophilus T-6. J. Bacteriol. 181 1999 3695-704 [PubMed: 10368143] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=10368143&action=stream&blobtype=pdf
	Dreyer JL. The role of iron in the activation of mannonic and altronic acid hydratases, two Fe-requiring hydro-lyases. Eur. J. Biochem. 166 1987 623-30 [PubMed: 3038546] http://dx.doi.org/10.1111/j.1432-1033.1987.tb13559.x

InterPro 23.1