The enzyme activities methylenetetrahydrofolate reductase (EC:1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC:1.7.99.5) differ in that the former (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while the latter (assigned in many bacteria) is flexible with respect to the acceptor. Both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as one or the other, this family describes the subset of proteins found in eukaryotes, and currently designated methylenetetrahydrofolate reductase (EC:1.5.1.20). This protein is an FAD-containing flavoprotein.
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